Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancer
Swiss Medical Weekly, 2011 QUESTIONS UNDER STUDY: Mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are two key components of the lectin-pathway of complement-activation. Information on the potential role of lectin-pathway components in carcinogenesis
UP Fisch +6 more
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Infusion of plasma-derived mannan-binding lectin (MBL) into MBL-deficient humans. [PDF]
Biochemical Society Transactions, 2003 To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldOur first experience of mannan-binding lectin (MBL)-replacement therapy was with a patient experiencing recurrent erythema multiforme associated
Valdimarsson, H
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Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design. [PDF]
Adv Sci (Weinh)Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Moon JH +8 more
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Dengue and the Lectin Pathway of the Complement System
Viruses, 2021 Dengue is a mosquito-borne viral disease causing significant health and economic burdens globally. The dengue virus (DENV) comprises four serotypes (DENV1-4).
Romchat Kraivong +4 more
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Serum levels, ontogeny and heritability of chicken mannan‐binding lectin (MBL) [PDF]
Immunology, 1998 Mannan‐binding lectin (MBL) is a serum lectin found in mammals and recently also in birds. It is thought to play an important role in the innate immune defence through binding to surface carbohydrates on micro‐organisms followed by complement activation via the MBL pathway. This results in opsonization or direct complement‐mediated killing.
Laursen, S B +5 more
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Engineered Dual-Function Antibody-Like Proteins to Combat SARS-CoV-2-Induced Immune Dysregulation and Inflammation. [PDF]
Adv Sci (Weinh)Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Wang Y +7 more
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Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease. [PDF]
PLoS Neglected Tropical Diseases, 2016 Chagas disease (CD) is caused by Trypanosoma cruzi, whose sugar moieties are recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that activates the lectin pathway of complement.
Paola Rosa Luz +6 more
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The Role of Mannan-Binding Lectin (MBL) Gene Polymorphism in Ulcerative Colitis. [PDF]
J Clin Biochem Nutr, 2008 Series studies suggest that enteropathogenic microorganisms play a substantial role in the clinical initiation and relapses of ulcerative colitis (UC). Mannan-binding lectin (MBL) is an important constituent of the innate immune system, and deficiency of MBL has been reported to increase the overall susceptibility of an individual to infectious disease.
Wang FY +6 more
europepmc +4 more sources
Reconstitution of Opsonizing Activity by Infusion of Mannan‐Binding Lectin (MBL) to MBL‐Deficient Humans [PDF]
Scandinavian Journal of Immunology, 1998 Mannan‐binding lectin (MBL, previously named mannan‐binding protein, MBP) is a serum collectin, which activates complement upon binding to microbial carbohydrates. This results in opsonization of the micro‐organisms as well as direct complement‐mediated killing.
Valdimarsson, H +6 more
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CD91 interacts with mannan‐binding lectin (MBL) through the MBL‐associated serine protease‐binding site [PDF]
The FEBS Journal, 2010 CD91 plays an important role in the scavenging of apoptotic material, possibly through binding to soluble pattern‐recognition molecules. In this study, we investigated the interaction of CD91 with mannan‐binding lectin (MBL), ficolins and lung surfactant proteins. Both MBL and L‐ficolin were found to bind CD91.
Duus, Karen +6 more
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