Results 41 to 50 of about 4,456 (216)

Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis

Renal Failure, 2022
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima, Dan Inoue, Takeaki Wajima, Takahiro Uchida, Muneharu Yamada, Isao Ohsawa, Takashi Oda   +6 more
doaj   +1 more source

Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin

Journal of Diabetes Research, 2017
Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of ...
Esben Axelgaard, Jakob Appel Østergaard, Steffen Thiel, Troels Krarup Hansen   +3 more
doaj   +1 more source

Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis

Journal of Biochemical and Clinical Genetics, 2021
Background: Systemic lupus erythematosus (SLE) is a complex trait characterized by the production of a range of autoantibodies and a diverse set of clinical phenotypes, including skin rash, neuropsychiatric and musculoskeletal symptoms, and lupus ...
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda   +4 more
doaj   +1 more source

Soluble Host Defense Lectins in Innate Immunity to Influenza Virus [PDF]

, 2012
Host defenses against viral infections depend on a complex interplay of innate (nonspecific) and adaptive (specific) components. In the early stages of infection, innate mechanisms represent the main line of host defense, acting to limit the spread of ...
Andrew G. Brooks, Michelle D. Tate, Patrick C. Reading, Wy Ching Ng   +3 more
core   +2 more sources

Interaction Properties of Human Mannan-Binding Lectin (MBL)-Associated Serine Proteases-1 and -2, MBL-Associated Protein 19, and MBL [PDF]

The Journal of Immunology, 2001
Abstract The mannan-binding lectin (MBL) activation pathway of complement plays an important role in the innate immune defense against pathogenic microorganisms. In human serum, two MBL-associated serine proteases (MASP-1, MASP-2) and MBL-associated protein 19 (MAp19) were found to be associated with MBL.
Thielens, N.M., Cseh, S., Thiel, S., Vorup-Jensen, Thomas, Rossi, V., Jensenius, J.C., Arlaud, G.J.   +6 more
openaire   +4 more sources

Perioperative mannan-binding lectin (MBL) patterns in cardiac surgery may correlate with the clinical outcomes in MBL deficient patients. [PDF]

Ann Thorac Surg, 2010
Previously we reported a case of abrupt change of postoperative mannan-binding-lectin (MBL) in a patient with preexisting MBL deficiency who expired shortly after cardiac surgery. Herein we report additional cases of 3 more patients with preexisting MBL deficiency who underwent cardiac surgery.
Hou YJ, Lee DC, Ko W, Kim A, Lee J, Shevde K, Zhang M.   +6 more
europepmc   +4 more sources

Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series [PDF]

, 2011
Introduction Eosinophilic meningitis, a potentially fatal disease caused by Angiostrongylus cantonensis, is considered an emerging infectious disease.
Bárbara Padilla-Docal, Alberto J Dorta-Contreras, Raisa Bu-Coifiu-Fanego, René H Martínez-Alderete, Olga Susana de Paula-Almeida, Hansotto Reiber, Jens Christian Jensenius   +6 more
core   +2 more sources

High normal TSH is associated with lower mannan-binding lectin in women of childbearing age

BMC Endocrine Disorders, 2020
Background Mannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Lower MBL levels are associated with, among other conditions, hypothyroidism and adverse pregnancy outcomes.
Malgorzata Karbownik-Lewinska, Jan Stepniak, Magdalena Marcinkowska, Adrian Krygier, Andrzej Lewinski   +4 more
doaj   +1 more source

Polymorphisms in Mannan-Binding Lectin (MBL)-Associated Serine Protease 2 Affect Stability, Binding to MBL, and Enzymatic Activity [PDF]

The Journal of Immunology, 2009
Abstract Mannan-binding lectin-associated serine protease 2 (MASP-2) is an enzyme of the innate immune system. MASP-2 forms complexes with the pattern recognition molecules mannan-binding lectin (MBL), H-ficolin, L-ficolin, or M-ficolin, and is activated when one of these proteins recognizes microorganisms and subsequently cleaves ...
Thiel, Steffen, Kolev, Martin, Degn, Søren Egedal, Steffensen, Rudi, Hansen, Annette, Ruseva, Marieta, Jensenius, Jens C   +6 more
openaire   +3 more sources

Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model

Journal of Diabetes Research, 2016
Background. Diabetic kidney disease is the leading cause of end-stage renal failure despite intensive treatment of modifiable risk factors. Identification of new drug targets is therefore of paramount importance.
Jakob Appel Østergaard, Marieta Milkova Ruseva, Talat Habib Malik, Ingeborg Torp Hoffmann-Petersen, Matthew Caleb Pickering, Steffen Thiel, Troels Krarup Hansen   +6 more
doaj   +1 more source