Results 81 to 90 of about 4,456 (216)

Leprosy association with low MASP-2 levels generated by MASP2 haplotypes and polymorphisms flanking MAp19 exon 5. [PDF]

PLoS ONE, 2013
BackgroundThe gene MASP2 (mannan-binding lectin (MBL)-associated serine protease 2) encodes two proteins, MASP-2 and MAp19 (MBL-associated protein of 19 kDa), bound in plasma to MBL and ficolins.
Angelica Beate Winter Boldt, Isabela Goeldner, Ewalda R S Stahlke, Steffen Thiel, Jens Christian Jensenius, Iara José Taborda de Messias-Reason   +5 more
doaj   +1 more source

Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism [PDF]

, 2017
Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation.
Dani, Ráhel, Dobó, József, Gál, Péter, Oroszlán, Gábor, Szilágyi, András, Thiel, Steffen, Závodszky, Péter   +6 more
core   +2 more sources

Exosomal‐complement system activation in preeclampsia

Journal of Obstetrics and Gynaecology Research, Volume 51, Issue 3, March 2025.
Abstract Aim Preeclampsia (PE) is a severe pregnancy‐related disorder characterized by hypertension and multi‐organ failure, primarily affecting the maternal vasculature and placenta. The aim of this review is to explain the molecular mechanisms behind PE by investigating the relationship between exosome release and complement activation, which could ...
M. David, N. Maharaj, A. Krishnan
wiley   +1 more source

Association between low levels of Mannan-binding lectin and markers of autoimmune thyroid disease in pregnancy. [PDF]

PLoS ONE, 2013
Functional deficiency of mannan-binding lectin (MBL) has been associated with adverse pregnancy outcome. Adverse events during pregnancy have also been described in women with autoimmune thyroid diseases (AITD), and thyroid hormones have been shown to ...
Eliska Potlukova, Tomas Freiberger, Zdenka Limanova, Jan Jiskra, Zdenek Telicka, Jana Bartakova, Drahomira Springer, Hana Vitkova, Marten Trendelenburg   +8 more
doaj   +1 more source

Mechanisms of immunity in acutely decompensated cirrhosis and acute‐on‐chronic liver failure

Liver International, Volume 45, Issue 3, March 2025.
Abstract The identification of systemic inflammation (SI) as a central player in the orchestration of acute‐on‐chronic liver failure (ACLF) has opened new avenues for the understanding of the pathophysiological mechanisms underlying this disease condition.
Cornelius Engelmann, Ingrid W. Zhang, Joan Clària   +2 more
wiley   +1 more source

The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics

The Scientific World Journal, 2013
The innate immune system is evolutionary and ancient and is the pivotal line of the host defense system to protect against invading pathogens and abnormal self-derived components. Cellular and molecular components are involved in recognition and effector
Ingrid Evans-Osses, Iara de Messias-Reason, Marcel I. Ramirez   +2 more
doaj   +1 more source

Complement anaphylatoxins: Potential therapeutic target for diabetic kidney disease

Diabetic Medicine, Volume 42, Issue 2, February 2025.
Abstract Diabetic kidney disease (DKD) is the most common cause of kidney failure, characterized by chronic inflammation and fibrosis. The complement system is increasingly implicated in the development and progression of diabetic nephropathy. The important complement anaphylatoxins C3a and C5a are key mediators of the innate immune system, which ...
Jingyuan Ma, Wai Han Yiu, Sydney C. W. Tang   +2 more
wiley   +1 more source

Membrane array and multiplex bead analysis of tear cytokines in systemic sclerosis [PDF]

, 2016
Although serious ocular manifestations of systemicsclerosis (SSc) have been described, tear analysis ofpatients with SSc has not been performed in previousstudies.
Hársfalvi, Jolán, Kemény-Beke, Ádám, Köröskényi, Krisztina, Rentka, Anikó, Szekanecz, Zoltán, Szodoray, Péter, Szűcs, Gabriella   +6 more
core   +1 more source

The complement system: A key player in the host response to infections

European Journal of Immunology, Volume 54, Issue 11, November 2024.
Duality of the complement system during infection: An adequate immune defense clears the infection and restores tissue resilience, whereas a maladaptive response due to complement hyperactivation results in hyperinflammation and tissue injury, as seen in sepsis and pneumonia.
Archana Jayaraman, Sarah Walachowski, Markus Bosmann   +2 more
wiley   +1 more source

SARS‐CoV‐2, periodontal pathogens, and host factors: The trinity of oral post‐acute sequelae of COVID‐19

Reviews in Medical Virology, Volume 34, Issue 3, May 2024.
Abstract COVID‐19 as a pan‐epidemic is waning but there it is imperative to understand virus interaction with oral tissues and oral inflammatory diseases. We review periodontal disease (PD), a common inflammatory oral disease, as a driver of COVID‐19 and oral post‐acute‐sequelae conditions (PASC). Oral PASC identifies with PD, loss of teeth, dysgeusia,
Joel Schwartz, Kristelle J. Capistrano, Joseph Gluck, Armita Hezarkhani, Afsar R. Naqvi   +4 more
wiley   +1 more source