Results 41 to 50 of about 416,662 (279)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Comparative Sentencing Practice [PDF]
, 1958 Uppsalas befintliga konstmuseum i Uppsala Slott har små och opraktiska lokaler. Uppsala Konstmuseis Vänner har därför lobbyat mot kommunen för att bygga ett nytt museum.
Mannheim, Hermann
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Energies, 2022 Nuclear power can replace fossil fuels and will have a decisive impact on the change in the approach to conventional energy. However, nuclear (or radioactive) wastes are produced by the operation of the nuclear reactors should be safely and properly ...
Mohamed Alwaeli, Viktoria Mannheim
doaj +1 more source
Torsion, Magnetic Monopoles and Faraday's Law via a Variational Principle
, 2014 Even though Faraday's Law is a dynamical law that describes how changing $\bf{E}$ and $\bf {B}$ fields influence each other, by introducing a vector potential $A_{\mu}$ according to $F_{\mu\nu}=\partial_{\mu}A_{\nu}-\partial_{\nu}A_{\mu}$ Faraday's Law ...
Mannheim, Philip D.
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
El hombre creyente y de hoy, ante la muerte
Estudios Eclesiásticos, 1987 El hombre actual se plantea la muerte de una forma diferente a como hacía en anteriores generaciones. Una parte de cultura la ha desacralizado por completo, haciendo de ella algo solo terreno.
Andrés Tornos Cubillo
doaj
EDUCAÇÃO FÍSICA, ESPORTE E LAZER À LUZ DA SOCIOLOGIA DO CONHECIMENTO DE MANNHEIM
Conexões, 2007 O presente texto apresenta a Sociologia do Conhecimento de Mannheim como um possível referencial teórico para se compreender o processo histórico da pluralidade de interpretações dos conceitos de Educação, Educação Física, Esporte e Lazer ...
Dagmar Hunger
doaj +1 more source