Results 41 to 50 of about 334,021 (288)

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

open access: yesAdvanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo   +7 more
wiley   +1 more source

A crítica da epistemologia na sociologia do conhecimento de Karl Mannheim

open access: yesSociedade e Estado, 2011
O artigo analisa a crítica da epistemologia normativa na obra de Karl Mannheim, sublinhando a sua presença tanto na fase mais filosófica, associada ao elogio do historicismo, como na Sociologia do Conhecimento posterior.
Luís de Gusmão
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

open access: yesAdvanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang   +9 more
wiley   +1 more source

Referate

open access: yesMeteorologische Zeitschrift, 1994
Lortz, Dietrich: Hydrodynamik. - BI-Hochschultaschenbuch, Bd. 696, Wissenschaftsverlag Mannheim-Leipzig-Wien-Zürich, 1993; Röth, E.-P.: Ozonloch - Ozonsmog: Grundlagen der Ozonchemie. Meyers Forum 26. - B.I. Taschenbuchverlag, Mannheim, 1994.
Hans Pichler, Stefan Emeis
doaj   +1 more source

Introduction to Otto Neurath’s “Bourgeois Marxism” (1930) and “Worldview and Marxism” (1931)

open access: yesSociologica, 2020
We are publishing two short pieces by Otto Neurath, a key figures in the Vienna Circle of logical empiricists, but also a social scientist close to the milieu of Austro-Marxism: "Bourgeois Marxism.
Alan Scott
doaj   +1 more source

Spatiotemporal Thermal Modulation and Patterning using a Programmable 1024 Element Microheater Array

open access: yesAdvanced Science, EarlyView.
Programmable microheater arrays are essential for a variety of applications. However, large arrays have thus far not been realized. We introduce a programmable 32×$\times$32 microheater array consisting of heating elements – each smaller than 300 μm$\umu{\rm m}$.
Rahul Goyal   +3 more
wiley   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

open access: yesAdvanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri   +3 more
wiley   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

open access: yesAdvanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han   +11 more
wiley   +1 more source

Hefftsche Kunstmühle A.G. Mannheim

open access: yes
HEFFTSCHE KUNSTMÜHLE A.G. MANNHEIM Hefftsche Kunstmühle A.G. Mannheim ( -
Kunstmühle A.G. Mannheim
core   +3 more sources

Extension of the CPT theorem to non-Hermitian Hamiltonians and unstable states

open access: yesPhysics Letters B, 2016
We extend the CPT theorem to quantum field theories with non-Hermitian Hamiltonians and unstable states. Our derivation is a quite minimal one as it requires only the time-independent evolution of scalar products, invariance under complex Lorentz ...
Philip D. Mannheim
doaj   +1 more source

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