Results 181 to 190 of about 61,569 (245)

Treatment landscape from first‐ to third‐line therapy and quality of life data of patients with pancreatic cancer from the prospective German PARAGON (Platform for Outcome, Quality of Life, and Translational Research on Pancreatic Cancer) registry (IKF‐PARAGON study)

International Journal of Cancer, Volume 158, Issue 10, Page 2560-2570, 15 May 2026.
What's New? Pancreatic cancer often is diagnosed at advanced stages. As a result, treatment regimens frequently are aggressive, with substantial side effects that impact quality of life (QoL). This study examined the treatment landscape, from neoadjuvant therapy to palliative care, in the context of QoL among pancreatic cancer patients in Germany. Most
Thorsten O. Goetze, Salah‐Eddin Al‐Batran, Ruediger Liersch, Lars Scheuer, Thomas Goehler, Ulrich Kaiser, Claudio Denzlinger, Stephan Brandl, Daniel Pink, Jens Uhlig, Michael Maasberg, Maria Loose, Marina Schaaf, Disorn Sookthai, Bianca Zäpf, Claudia Pauligk, Timursah Habibzade, Ralf‐Dieter Hofheinz, Christine Koch, for the AIO Study Group   +19 more
wiley   +1 more source

Cancer-control outcomes of patients with metastatic hormone-sensitive prostate cancer and ≥ 10 bone metastases receiving apalutamide: a real-world cohort. [PDF]

BMC Cancer
Wenzel M, Filzmayer M, Siech C, Le QC, Lauer B, Theissen L, Hoeh B, Heinzer H, Graefen M, Steuber T, Kriegmair M, Chun FK, Mandel P.   +12 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Clinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis. [PDF]

Clin Transl Radiat Oncol
Wurschi GW, Schneider M, Becker JN, Frerker B, Vorbach SM, Ehret F, Diefenhardt M, Schunn F, von Gruben ME, Büttner M, Hoffmann E, Rühle A, Beier J, Ferdinandus S, Trommer M, Sahin EC, Hlouschek J, Aninditha K, von Ohlen DS, Kaufmann J, Depardon A, Ha HM, Kessler C, Cieslak A, Trommer S, Fabian A, Sonnhoff M, Rißner F, Römer M, Pietschmann K.   +29 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A pragmatic evaluation of serum IL-6, PCT and CRP compared to routine CSF biomarkers and CDC/IDSA criteria in healthcare-associated Ventriculitis. [PDF]

Surg Neurol Int
Bexten T, Albrecht K, Bushuven S, Klein J, Lindern HA, Schneider-Lindner V.   +5 more
europepmc   +1 more source

Information retrieval or document retrieval? Terminological confusions and unrealistic goals in information science, exemplified in relation to generative artificial intelligence

Journal of the Association for Information Science and Technology, Volume 77, Issue 5, Page 714-726, May 2026.
Abstract ChatGPT and related technologies have revived an old issue in information science (IS) concerning information retrieval (IR) versus document retrieval. Since 1950, the term IR has primarily been used as a misnomer for document retrieval. This problematic terminology reflects a desire to go beyond documents and provide, in response to user ...
Birger Hjørland
wiley   +1 more source

Intraoperative radiotherapy in elderly patients with breast cancer: long-term follow-up results of the prospective phase II trial TARGIT-E. [PDF]

BMC Cancer
Sperk E, Lemanski C, Neumaier C, Lauer J, Siefert V, Völker R, Lindner C, Niehoff P, Tallet AR, Racadot S, Petit A, Pazos M, Le-Blanc Onfroy M, Martin E, Reuter C, Hermann RM, Pohl F, Friedrichs K, Würschmidt F, Pigorsch S, Kolberg HC, Graf H, Brunner TB, Malter W, Park-Simon TW, Brucker C, Fleckenstein J, Petersen C, Tuschy B, Wilken EE, Büttner S, Sütterlin M, Flyger H, Wenz F.   +33 more
europepmc   +1 more source

Combinatorial Screening in Electrochemical Reaction Engineering

Chemie Ingenieur Technik, Volume 98, Issue 5, Page 235-244, May 2026.
Parallel testing (combinatorial screening) accelerates climate‐friendly materials research. This study advances high‐pressure electrocatalysis with automated reaction and analytics. A compressible cell enables PEM water electrolysis at elevated pressure.
Stefan Bowe, Inka Dessel, Florian Huber, Asha Jacob, Andreas Müller, Oliver Püttmann, Ralf Kuppinger, Kevin Stojanovski, Guido Wasserschaff, Deniz Dogan, Rüdiger‐Albert Eichel, Burkhard Hecker, Xuehuai Hou, André Karl, Andrei Salavei, Hermann Tempel, Niklas Wolf, Volkmar M. Schmidt, Jonas Hein, Hans‐Joachim Kost, Patrick Löb, Athanassios Ziogas   +21 more
wiley   +1 more source

Improving cardiovascular risk stratification through the derivation and validation of an elevated triglyceride-glucose index. [PDF]

Diabetes Obes Metab
Mavraganis G, Georgiopoulos G, Athanasopoulos S, Terentes-Printzios D, Zervas G, Konstantaki C, Koilakou ME, Giannakopoulou SP, Dimopoulou MA, Chrysochoou C, Tsioufis K, Pitsavos C, Liberopoulos E, Stellos K, Vlachopoulos C, Panagiotakos D, Stamatelopoulos K.   +16 more
europepmc   +1 more source