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Cardiovascular Diseases and Mannose-Binding Lectin
Kardiologiia, 2014The role of innate immunity factors in the pathogens of ACS is not well studied, although there is evidence in the literature about their impact on the course of cardiovascular diseases. Mannose-binding lectin (MBL)--one of the key factors of the humoral innate immune system that activates one of complement activation pathways.
I E, Losin +3 more
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Ureaplasma urealyticum binds mannose-binding lectin
Experimental and Molecular Pathology, 2004Mannose-binding C-type lectin (MBL) is an important component of innate immunity in mammals. Mannose-binding lectin (MBL), an acute phase protein, acts as an opsonin for phagocytosis and also activates the mannan-binding lectin complement pathway. It may play a particularly significant role during infancy before adequate specific protection can be ...
Barbara D, Benstein +3 more
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Mannose‐binding lectin and vulvovaginal candidiasis
International Journal of Gynecology & Obstetrics, 2005AbstractObjective: To investigate the effect of mannose‐binding lectin (MBL) gene polymorphism on the immune system and the significance of vaginal MBL concentration in the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (rVVC). Patients and methods: Mannose‐binding lectin concentrations in CVL samples from 111 women were collected ...
Fei, Liu, Qinping, Liao, Zhaohui, Liu
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Mannose binding lectin gene polymorphisms and asthma
Clinical & Experimental Allergy, 2007SummaryBackground Bronchial asthma is a chronic inflammatory disorder of the airways. Recently, it has been suggested that complement plays significant roles in asthma. Mannose‐binding lectin (MBL) is one of the key molecules in complement activation pathways that are associated with several infectious and immune disorders.Subjects and method
X, Wang +5 more
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Anti-microbial activities of mannose-binding lectin
Biochemical Society Transactions, 2003Mannose-binding lectin (MBL; also known as mannan-binding lectin) is involved in first-line defence by binding to bacteria, viruses, protozoa and helminths through a pattern-recognition mode of detection and then initiating a range of host responses. Currently, we have been unable to extrapolate from what we know of the biochemistry of MBL binding to ...
D L, Jack, M W, Turner
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2008
Abstract Mannose-binding lectin (MBL) is an important component of the innate immune system. MBL belongs to the family of proteins called collectins, which contain both collagen-like domains and C-type lectin domains. The human collectin family includes MBL and lung surfactant proteins A and D (Holmskov et al., 1994; Lu, 1997; Lu et al.,
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Abstract Mannose-binding lectin (MBL) is an important component of the innate immune system. MBL belongs to the family of proteins called collectins, which contain both collagen-like domains and C-type lectin domains. The human collectin family includes MBL and lung surfactant proteins A and D (Holmskov et al., 1994; Lu, 1997; Lu et al.,
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Mannose‐binding lectin: biology and clinical implications
Internal Medicine Journal, 2005Abstract The innate host defence molecule mannose‐binding lectin (MBL) has attracted great interest as a potential candidate for passive immunotherapy to prevent infection. MBL is a multimeric lectin that recognizes a wide array of pathogens independently of specific antibody, and initiates the lectin pathway of complement activation.
D L, Worthley +2 more
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Mannose binding lectin: Genetics and autoimmune disease
Autoimmunity Reviews, 2005Mannose binding lectin (MBL) is a serum protein with structure and functions similar to those of complement factor C1q, and is a key molecule in innate immunity. Interestingly, absence or extremely low concentration of serum MBL (MBL deficiency) seems to be a risk factor for occurrence of autoimmune diseases, in particular systemic lupus erythematosus.
Akito, Tsutsumi +2 more
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Mannose-Binding Lectins in Cerebrum Development
2003The nervous system is so complex that it is not ordinarily considered as an interesting model for studying cellular mechanisms. However, its morphology (at least in some well-defined areas) provides essential information because cells are polarised: cell body, axons and dendrites can be easily identified in vivo, an essential property when studies are ...
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Mannose-binding lectin shows its value
Trends in Immunology, 2001The plasma protein mannose-binding lectin (MBL) binds to carbohydrate moieties found on the surface of a range of microorganisms. Once bound, the protein activates complement, leading to increased phagocytosis and lysis of the foreign surface. Low levels of MBL are common to all populations, but the relative importance of this component of the innate ...
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