Results 101 to 110 of about 15,589 (264)

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Investigation of Mannose–Binding Lectin Level and Deficiency in Patients with Dermatophytosis [PDF]

, 2013
Mehraban Falahati, Sanam Nami, Zeini Farideh, Mohsen Ghelman, Zeinab Ghasemi, Shima Nozari   +5 more
openalex   +1 more source

Steroid‐Refractory Cryptogenic Organising Pneumonia (COP) in a Patient With Mannose‐Binding Lectin (MBL) Deficiency

Respirology Case Reports, Volume 14, Issue 2, February 2026.
A 67‐year‐old man with cryptogenic organising pneumonia developed recurrent relapses despite corticosteroid and mycophenolate therapy. A complete absence of mannose‐binding lectin was identified, suggesting impaired apoptotic cell clearance as a contributor to persistent inflammation.
Ilias E. Dimeas, Sotirios I. Sinis, Paraskevi Kirgou, Cormac McCarthy, Zoe Daniil   +4 more
wiley   +1 more source

Computational insights into the circular permutation roles on ConA binding and structural stability

Current Research in Structural Biology
The mechanisms behind Concanavalin A (ConA) circular permutation have been under investigation since 1985. Although a vast amount of information is available about this lectin and its applications, the exact purpose of its processing remains unclear.
Vinicius J.S. Osterne, Vanir R. Pinto-Junior, Messias V. Oliveira, Kyria S. Nascimento, Els J.M. Van Damme, Benildo S. Cavada   +5 more
doaj   +1 more source

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis [PDF]

, 2016
Katrine Pilely, Anne Rosbjerg, Ninette Genster, Péter Gál, Gábor Pál, Bente Halvorsen, Sverre Holm, Pål Aukrust, Siril S. Bakke, Bjørnar Sporsheim, Ingunn Nervik, Nathalie Niyonzima, Emil D. Bartels, Gregory L. Stahl, Tom Eirik Mollnes, Terje Espevik, Peter Garred   +16 more
openalex   +1 more source

KM+, a mannose‐binding lectin from artocarpus integrifolia: Amino acid sequence, predicted tertiary structure, carbohydrate recognition, and analysis of the β‐prism fold [PDF]

, 1999
José Cesar Rosa, Lewis Joel Greene, Paulo Sérgio Lopes de Oliveira, Richard Charles Garratt, Leila Maria Beltramini, Katheryn A. Resing, Maria Cristina Roque‐Barreira   +6 more
openalex   +1 more source

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency [PDF]

, 2010
Xavier Vallès, Anna Roca, Francisco Lozano, L. Morais, B. Suárez, Ferrán Casals, Inácio Mandomando, Betuel Sigaúque, Delino Nhalungo, Cristina Esquinas, Llorenç Quintó, Pedro L. Alonso, A. M. Torres   +12 more
openalex   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source