Results 11 to 20 of about 25,372 (246)

Identification of SARS-CoV-2-binding lectins on a commercial lectin array [PDF]

Scientific Reports
The Spike glycoprotein of SARS-CoV-2 is the major target for vaccines and therapeutics. Spike glycosylation is critical for ACE2 binding and subsequent viral fusion and entry.
Neetu, Shimona Ahlawat, Rathina Delipan, Rajesh P. Ringe, Alka Rao, T. N. C. Ramya   +5 more
doaj   +2 more sources

Altering the carbohydrate-binding specificity of the legume lectin FRIL through structure-guided engineering [PDF]

Nature Communications
FRIL is a legume lectin from the hyacinth bean that has broad-spectrum antiviral activity. A distinctive trait of FRIL among similar mannose/glucose-specific legume lectins is that FRIL shows specificity for complex type N-glycans.
Yo-Min Liu, Hong Thuy Vy Nguyen, Xiaorui Chen, Md. Shahed-Al-Mahmud, Ting-Hua Chen, Kuo-Shiang Liao, Jennifer M. Lo, Tzu-Chun Kan, Chien-Tai Ren, Che Ma   +9 more
doaj   +2 more sources

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference [PDF]

Nature Communications
A critical step in infections is the attachment of microorganisms to host cells using lectins that bind glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH, an adhesin in E.
Kelli L. Hvorecny, Gianluca Interlandi, Tim S. Veth, Pavel Aprikian, Anna Manchenko, Veronika L. Tchesnokova, Miles S. Dickinson, Joel D. Quispe, Nicholas M. Riley, Rachel E. Klevit, Pearl Magala, Evgeni V. Sokurenko, Justin M. Kollman   +12 more
doaj   +2 more sources

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients With Type 2 Diabetes: A Multicenter Prospective Study With 5-Year Follow Up (U-CARE Study 2)

Frontiers in Cardiovascular Medicine, 2021
Background: Although various biomarkers predict cardiovascular event (CVE) in patients with diabetes, the relationship of urinary glycan profile with CVE in patients with diabetes remains unclear.Methods: Among 680 patients with type 2 diabetes, we ...
Koki Mise, Mariko Imamura, Satoshi Yamaguchi, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Satoshi Miyamoto, Haruhito A. Uchida, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Takashi Matsuoka, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhiro Miyashita, Shinichiro Ando, Tomokazu Nunoue, Michihiro Yoshida, Masao Yamada, Kenichi Shikata, Jun Wada   +24 more
doaj   +1 more source

Mannose‐binding lectin and gastric cancer [PDF]

International Journal of Cancer, 2007
Daniel L. Worthley*, Peter G. Bardy, David L. Gordon and Charles G. Mullighan Department of Gastroenterology and Hepatology, Flinders Medical Centre, South Australia, Australia Division of Hematology, Royal Adelaide Hospital and Institute of Medical and Veterinary Science, South Australia, Australia Department of Hematology–Oncology, The Queen ...
Worthley, D., Bardy, P., Gordon, D., Mullighan, C.   +3 more
openaire   +3 more sources

The carbohydrate-binding specificity and molecular modelling of Canavalia maritima and Dioclea grandiflora lectins

Memorias do Instituto Oswaldo Cruz, 1996
The carbohydrate-binding specificity of lectins from the seeds of Canavalia maritima and Dioclea grandiflora was studied by hapten-inhibition of haemagglutination using various sugars and sugar derivatives as inhibitors, including N-acetylneuraminic acid
Márcio Viana Ramos, Renato de Azevedo Moreira, José Tadeu Abreu Oliveira, Benildo Sousa Cavada, Pierre Rougé   +4 more
doaj   +1 more source

Protein-carbohydrate interactions during fertilization [PDF]

, 1998
Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Kolle, S., Plendl, J., Sinowatz, Fred
core   +1 more source

Insecticidal activity of a protein extracted from bulbs of Phycella australis Ravenna against the aphids Acyrthosiphon pisum Harris and Myzus persicae Sulzer [PDF]

, 2016
Aphids cause significant losses in many agricultural crops and in many cases cause repeated insecticide sprays, which increase the risk of resistance. Therefore, other alternatives are needed to control them.
Devotto, Luis, Smagghe, Guy, Van Damme, Els, Vargas, Marisol, Zapata, Nelson   +4 more
core   +2 more sources

The ‘involution’ of mannose-binding lectin [PDF]

Human Molecular Genetics, 2005
Mannose-binding lectin (MBL) acts as a serum opsonin in innate immune defense and induces complement activation by the lectin pathway. In humans, low levels of functional serum MBL are caused by the dominant action of three single nucleotide substitutions in exon 1 that disrupt the glycine-rich backbone structure of the protein.
Jeanette, Seyfarth, Peter, Garred, Hans O, Madsen   +2 more
openaire   +2 more sources

The Third Dimension of Reading the Sugar Code by Lectins [PDF]

, 2013
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
André, Sabine, Gabius, Hans-Joachim, Murphy, Paul V.   +2 more
core   +3 more sources