Results 181 to 190 of about 87,443 (234)

Mannose-binding lectin deficiency—revisited

Molecular Immunology, 2003
There is an emerging interest for mannose-binding lectin (MBL) due to its role in innate immunity. In this survey we present a mixture of old and new data describing the effect MBL polymorphisms may have on the level and function of the molecule. Three single nucleotide substitutions in exon 1 of the mbl2 gene cause a dominant decrease of functional ...
Garred, I., Larsen, F., Madsen, H.O., Koch, C.   +3 more
openaire   +3 more sources

Ureaplasma urealyticum binds mannose-binding lectin

Experimental and Molecular Pathology, 2004
Mannose-binding C-type lectin (MBL) is an important component of innate immunity in mammals. Mannose-binding lectin (MBL), an acute phase protein, acts as an opsonin for phagocytosis and also activates the mannan-binding lectin complement pathway. It may play a particularly significant role during infancy before adequate specific protection can be ...
Barbara D, Benstein, Donald D, Ourth, Dennis T, Crouse, D Radford, Shanklin   +3 more
openaire   +2 more sources

Mannose‐binding lectin and innate immunity

Immunological Reviews, 2009
Summary:  Innate immunity is the earliest response to invading microbes and acts to contain infection in the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal expansion of cells that emerge days after antigenic challenge, the innate immune response is immediate.
W K Eddie, Ip, Kazue, Takahashi, R Alan, Ezekowitz, Lynda M, Stuart   +3 more
openaire   +2 more sources

Secreted NS1 protects dengue virus from mannose binding lectin-mediated neutralization

Journal of Immunology, 2016
Flavivirus nonstructural protein 1 (NS1) is a unique secreted nonstructural glycoprotein. Although it is absent from the flavivirus virion, intracellular and extracellular forms of NS1 have essential roles in viral replication and the pathogenesis of ...
Somchai Thiemmeca, Chamaiporn Tamdet, Nuntaya Punyadee, Tanapan Prommool, Adisak Songjaeng, S. Noisakran, C. Puttikhunt, J. Atkinson, M. Diamond, A. Ponlawat, Panisadee Avirutnan   +10 more
semanticscholar   +1 more source

Mannose binding lectin (MBL) and HIV

Molecular Immunology, 2005
The envelope protein (gp120/gp41) of HIV-1 is highly glycosylated with about half of the molecular mass of gp120 consisting of N-linked carbohydrates. While glycosylation of HIV gp120/gp41 provides a formidable barrier for development of strong antibody responses to the virus, it also provides a potential site of attack by the innate immune system ...
Xin, Ji, Henry, Gewurz, Gregory T, Spear
openaire   +2 more sources

Mannose‐binding lectin and vulvovaginal candidiasis

International Journal of Gynecology & Obstetrics, 2005
AbstractObjective: To investigate the effect of mannose‐binding lectin (MBL) gene polymorphism on the immune system and the significance of vaginal MBL concentration in the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (rVVC). Patients and methods: Mannose‐binding lectin concentrations in CVL samples from 111 women were collected ...
Fei, Liu, Qinping, Liao, Zhaohui, Liu
openaire   +2 more sources

Mannose-binding lectin levels in endometriosis

Fertility and Sterility, 2010
The serum concentrations of mannose-binding lectin in patients with or without endometriosis do not differ. Mannose-binding lectin could be involved in the modulation of inflammatory responses, but it does not seem to take part in endometriosis pathogenesis.
ORAL, HALUK BARBAROS, Uncu, Guerkan, ÖZERKAN, Kemal Nuri   +2 more
openaire   +3 more sources

Cardiovascular Diseases and Mannose-Binding Lectin

Kardiologiia, 2014
The role of innate immunity factors in the pathogens of ACS is not well studied, although there is evidence in the literature about their impact on the course of cardiovascular diseases. Mannose-binding lectin (MBL)--one of the key factors of the humoral innate immune system that activates one of complement activation pathways.
I E, Losin, R M, Shakhnovich, K A, Zykov, M Ia, Ruda   +3 more
openaire   +2 more sources

Targeting Mannose Binding Lectin Confers Long Lasting Protection with a Surprisingly Wide Therapeutic Window in Cerebral Ischemia

Circulation, 2012
Background— The involvement of the complement system in brain injury has been scarcely investigated. Here, we document the pivotal role of mannose-binding lectin (MBL), one of the recognition molecules of the lectin complement pathway, in brain ischemic ...
F. Orsini, P. Villa, Sara Parrella, R. Zangari, E. Zanier, R. Gesuete, M. Stravalaci, S. Fumagalli, R. Ottria, J. Reina, Alessandra Paladini, E. Micotti, R. Ribeiro-Viana, J. Rojo, V. Pavlov, G. Stahl, A. Bernardi, M. Gobbi, M. D. De Simoni   +18 more
semanticscholar   +1 more source

Anti-microbial activities of mannose-binding lectin

Biochemical Society Transactions, 2003
Mannose-binding lectin (MBL; also known as mannan-binding lectin) is involved in first-line defence by binding to bacteria, viruses, protozoa and helminths through a pattern-recognition mode of detection and then initiating a range of host responses. Currently, we have been unable to extrapolate from what we know of the biochemistry of MBL binding to ...
D L, Jack, M W, Turner
openaire   +2 more sources