Results 121 to 124 of about 456 (124)

Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris , Candida albicans , Candida parapsilosis , and Candida glabrata ( Nakaseomyces glabratus )

Abstract The fungal pathogenCandida aurisis of global concern due to high levels of multidrug resistance and its propensity to cause infectious outbreaks. Over 90% of isolates are resistant to fluconazole, the most commonly prescribed antifungal world-wide.
Katherine S. Barker, Hoja P. Patterson, Joachim Morschhäuser, Christina A. Cuomo, Nathan P. Wiederhold, P. David Rogers   +5 more
openaire   +1 more source

The Discovery of Manogepix/Fosmanogepix and Other Gwt1 Inhibitors for the Treatment of Invasive Fungal Infections

2019
Jonathan A. Covel, Quinlyn A. Soltow, Mili Kapoor, Molly K. Moloney, Peter J. Webb, Michael Trzoss, Marc Sharp, Karen Joy Shaw   +7 more
openaire   +1 more source

Synthesis of analogs of the Gwt1 inhibitor manogepix (APX001A) and in vitro evaluation against Cryptococcus spp

Bioorganic and Medicinal Chemistry Letters, 2019
exaly  

The susceptibility of Meyerozyma guilliermondii and Kluyveromyces marxianus to manogepix and other antifungal drugs

CMI Communications
Konarska, D., Pucek, J., Korzeniowska-Kowal, A.   +2 more
openaire   +1 more source