Results 61 to 70 of about 84,950 (309)

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit   +14 more
wiley   +1 more source

Obtaining adjusted prevalence ratios from logistic regression model in cross-sectional studies

, 2014
In the last decades, it has been discussed the use of epidemiological prevalence ratio (PR) rather than odds ratio as a measure of association to be estimated in cross-sectional studies.
Bastos, Leonardo Soares, de Oliveira, Raquel de Vasconcellos Carvalhaes, Velasque, Luciane de Souza   +2 more
core   +2 more sources

Levosimendan for patients with severely reduced left ventricular systolic function and/or low cardiac output syndrome undergoing cardiac surgery. a systematic review and meta-analysis [PDF]

, 2017
Background: Previous studies have shown beneficial effects of levosimendan in high-risk patients undergoing cardiac surgery. Two large randomized controlled trials (RCTs), however, showed no advantages of levosimendan.
Arcadipane, Antonio, Knight, Joshua B., Lorini, Ferdinando L., Morelli, Andrea, Pastore, Federico, Sanfilippo, Filippo, Santonocito, Cristina, Scolletta, Sabino, Tritapepe, Luigi   +8 more
core   +2 more sources

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Persepsi Perlindungan Hukum dan Aspek Etik terhadap Keinginan Perawat IGD Melakukan CPR pada Out-of-Hospital Cardiac Arrest (OHCA)

Jurnal Pendidikan Keperawatan Indonesia, 2020
ABSTRAK Kejadian henti jantung dapat terjadi dimana saja baik di rumah sakit maupun di luar rumah sakit atau Out-of-Hospital Cardiac Arrest (OHCA).
Wiwin Winarti, Rosiana Rosiana
doaj   +1 more source

Efficacy and Safety of ABBV‐154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo‐Controlled Trial

Arthritis &Rheumatology, Accepted Article.
Objective Despite availability of biologics and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) to treat rheumatoid arthritis (RA), many patients do not experience optimized disease control. Glucocorticoids are effective but have safety risks.
Frank Buttgereit, Atul Singhal, Alan Kivitz, Edit Drescher, Yoshinori Taniguchi, Rosalía Martínez Pérez, Jaclyn Anderson, Ronilda D'Cunha, Weihan Zhao, Nicholas DeVogel, Julie Parmentier, Romy Christmann, Dilek Arikan, Howard Amital   +13 more
wiley   +1 more source

Differential Item Functioning Analysis of the Mental, Emotional, and Bodily Toughness Inventory [PDF]

, 2012
This study was to use differential item functioning (DIF) analysis to examine if there were items in the Mental, Emotional, and Bodily Toughness Inventory (MeBTough) functioning differently across gender and athletic membership. A total of 444 male (56.3%
Gao, Yong, Mack, Mick G., Ragan, Brian, Ragan, Moira A.   +3 more
core   +2 more sources

The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta‐Analysis

Autism Research, EarlyView.
ABSTRACT Maternal asthma has been linked to child autism. In this study, we systematically reviewed observational studies published between July 2001 and February 2024 that assessed maternal asthma during pregnancy (exposure) and child autism (outcome). Databases searched included MEDLINE, CINAHL, EMBASE, and PsycINFO.
Renee van der Schaaf, Vanessa E. Murphy, Soriah Harvey, Paige Dent, Alison Lane, Olivia Whalen   +5 more
wiley   +1 more source

ANALYSIS OF DIFFERENTIAL ITEM FUNCTION (DIF) COATS-Haenszel USING DIFFERENT AREAS UNDER THE TOWN AND VILLAGE IN NATIONAL TEST DEVICE IN BANTEN IPA SD ( Primary School)

JISAE (Journal of Indonesian Student Assessment and Evaluation), 2017
Analysis of Differential Item Function (DIF) / otherness Function Item is an analysis conducted on a set of tests to determine the bias point. Bias grains occur because of differences in background of respondents test, while a good test devices have ...
Sukemi .
doaj   +1 more source

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +1 more source