Results 141 to 150 of about 58,594 (258)

Dispersal, source and glass chemistry of a third tephra unit within Iceland's Settlement Layer

Boreas, EarlyView.
Tephra layers may be studied to understand the dynamics and sequence of past explosive volcanism. In Iceland, the distinctive Settlement Layer (AD ~877) underlies almost all archaeological evidence for the Norse Settlement and is preserved in soils across Iceland and as cryptotephra overseas.
Conner A. G. Morison, GuÐrún Larsen, Anthony J. Newton, Andrew J. Dugmore   +3 more
wiley   +1 more source

Granitic intrusions enhance strain localization and rapid mantle exhumation along an oceanic detachment fault. [PDF]

Sci Adv
Poulaki EM, Bickert M, Vannucchi P, Shuck BD, Akizawa N, Pandey A, Morishita T, Sanfilippo A, Cunningham EH, Barnes JD, Garber JM, Nistor C, Bernard R, Tribuzio R, Loocke M, Abe N, Di Stefano A, Filina IY, Fu Q, Gontharet SBL, Kearns LE, Koorapati RK, Lei C, Loreto MF, Magri L, Menapace W, Pavlovics VL, Pezard PA, Rodriguez-Pilco MA, Zhao X, Pérez-Gussinyé M, Garrido CJ, Ranero CR, Estes ER, Malinverno A, Zitellini N.   +35 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Formation of calcium silicate perovskite above the core-mantle boundary during solidification of Earth's magma ocean. [PDF]

Sci Adv
Wang T, Badro J, Caracas R, Gendre H, Hébert C.   +4 more
europepmc   +1 more source

Bruton tyrosine kinase inhibitors and cardiovascular adverse events

British Journal of Pharmacology, EarlyView.
Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli, Cristina Madaudo, Emanuela Salvatorelli, Giorgio Minotti, Pierantonio Menna   +4 more
wiley   +1 more source

Deep mantle anomalies block early Earth melting, challenging a primordial origin. [PDF]

Sci Rep
Roy A, Mittelstaedt E, Cooper CM.
europepmc   +1 more source

Mitochondrial Morphology Dynamics Remodel Metabolism and Affect TKI Sensitivity in EGFR‐Mutated Lung Cancer

Cancer Science, EarlyView.
TKI treatment promotes mitochondrial fission and metabolic reprogramming toward oxidative phosphorylation in residual EGFR‐mutant lung cancer cells. Targeting this metabolic vulnerability restores TKI sensitivity and provides a promising strategy to overcome acquired resistance.
Yu Zhao, Yuqiang Liu, Mingxuan Xie, Zhiming Ye, Hong Huang, Maojin Yao, Feng Zhou, Jianzhu Zhao, Jun Tang   +8 more
wiley   +1 more source

Cement mantle thickness in total knee arthroplasty more closely associated with tibial bone density than cement viscosity : findings from a randomized controlled trial. [PDF]

Bone Jt Open
Mikashima Y, Imamura H, Yano K, Ikari K, Takagi H, Okazaki K.   +5 more
europepmc   +1 more source

Clues of ancient incomplete lineage sorting during bivalve evolution undermine support for Heterodonta

Cladistics, EarlyView.
Abstract A long‐standing challenge in phylogenomics has been the resolution of relationships originated from ancient radiations. In these cases, phenomena such as incomplete lineage sorting can increase the support for conflicting resolutions. Most of the diversity in the Class Bivalvia originated during an Ordovician radiation; indeed, several deep ...
Alessandro Formaggioni, Takeshi Takeuchi, Mayuko Hamada, Kazuhiro Saito, Tatsuya Sakamoto, Noriyuki Satoh, Federico Plazzi, Marco Passamonti   +7 more
wiley   +1 more source

From magma ocean to core-mantle boundary: the key role of hydrous ferropericlase in shaping deep Earth's low-velocity anomalies. [PDF]

Natl Sci Rev
Guan SD, Wang Y, Du ZX, Yang YN, Xu YG.
europepmc   +1 more source