Results 151 to 160 of about 58,594 (258)

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Correction for Ajourlou et al., Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice-Earth interactions in Greenland. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Progressive sub-arc mantle oxidation modulated by sediment melt. [PDF]

Sci Adv
Gao M, Wang Y, Xu YG.
europepmc   +1 more source

Post‐Transplant Bendamustine as a Platform for Immune Modulation After Allogeneic Hematopoietic Cell Transplantation

European Journal of Haematology, EarlyView.
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo, Richard J. Simpson, Emmanuel Katsanis   +2 more
wiley   +1 more source

Preliminary Descriptive Characterization Reveals Physicochemical Differentiation of Tissue Mucus in <i>Crassostrea gigas</i>. [PDF]

Materials (Basel)
Cui S, Wang X, Liu N, Wang X.
europepmc   +1 more source

Difference and the Liberation of Sufficient Reason

European Journal of Philosophy, EarlyView.
Abstract The Principle of Sufficient Reason (PSR) holds that every event and entity can be explained by a sufficient reason or cause. Philosophers have long struggled with the question of the PSR's compatibility with freedom, for if what occurs or exists follows necessarily from its sufficient reason then it seems it could not have been otherwise ...
Louis Matheou
wiley   +1 more source

Linking carbonatites, rare earth ores, and subduction-fertilized mantle lithosphere. [PDF]

Sci Adv
Spandler C, Merdith AS, Griffin A.
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Spatially microdissected profiling of tonsillar germinal centers reveals a KLRG1-enriched immune signature in IgA nephropathy. [PDF]

Front Immunol
Kawabe M, Yamamoto I, Ohki Y, Hayashi A, Kanzaki G, Matsumoto K, Ueda H, Hirano K, Tsuboi N, Yokoo T.   +9 more
europepmc   +1 more source

Temporal dynamics of immune effector cell‐associated haematotoxicity: Linking early and late cytopenias after chimeric antigen receptor T cells

British Journal of Haematology, EarlyView.
Malvina Bichon, Roch Houot, Mana Alshehri, Guillaume Manson, Faustine Lhomme, Samuel Vic   +5 more
wiley   +1 more source