Results 51 to 60 of about 29,712 (190)

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Evaluation of different media for cell proliferation in mantle tissue culture of the green mussel, Perna viridis (Linnaeus, 1758) [PDF]

, 2017
The aim of the present study was to establish a suitable culture system for tissue explants from the mantle of the green mussel, Perna viridis. The experiments were conducted using healthy, live green mussels in the size range of 75 to 110 g collected ...
C. P. Suja, Divipala, Indira, Jayasankar, Vidya, Suja, C P, Vijayan, K K, B. Koncies Mary, Koncies Mary, B, I. Divipala, Srinivasa Raghavan, V, Bareen Mohamed, M, VIDYA Jayasankar, M. Bareen Mohamed, V. Srinivasa Raghavan, K. K. Vijayan   +13 more
core   +1 more source

Functional zones of Peyer’s patch (PPs) in rabbits’ caecum

Theoretical and Applied Veterinary Medicine, 2021
A feature of rabbit gut-associated lymphoid tissue is that its structure is more developed than in other animal species. In rabbits it is composed of sacculus rotundus, vermiform appendix and Peyer’s patches.
M. O. Nikitina, M. V. Kravtsova, A. A. Bohomaz   +2 more
doaj   +1 more source

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

British Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Epigenetic variation mediated by lncRNAs accounts for adaptive genomic differentiation of the endemic blue mussel Mytilus chilensis

Heliyon
Epigenetic variation affects gene expression without altering the underlying DNA sequence of genes controlling ecologically relevant phenotypes through different mechanisms, one of which is long non-coding RNAs (lncRNAs).
Marco Yévenes, Cristian Gallardo-Escárate, Gonzalo Gajardo   +2 more
doaj   +1 more source

Enemy release: loss of parasites in invasive freshwater bivalves Sinanodonta woodiana and Corbicula fluminea

Ecography, EarlyView.
Invasive freshwater bivalves harm native species, ecosystems and biodiversity, and incur economic costs. The enemy release hypothesis posits that invasive species are released from enemies during the invasion process, giving them a competitive advantage in the new environment.
Binglin Deng, Nicoletta Riccardi, Pin Nie, Maria Urbańska, Timo J. Marjomäki, Wojciech Andrzejewski, Małgorzata Ożgo, Keiko Nakamura, Jouni Taskinen   +8 more
wiley   +1 more source

Global Patterns of Gene Regulation Associated with the Development of Ectomycorrhiza Between Birch (Betula pendula Roth.) and Paxillus involutus (Batsch) Fr.

Molecular Plant-Microbe Interactions, 2005
The formation of ectomycorrhizal (ECM) root tissue is characterized by distinct morphological and developmental stages, such as preinfection and adhesion, mantle, and Hartig net formation.
Antoine Le Quéré, Derek P. Wright, Bengt Söderström, Anders Tunlid, Tomas Johansson   +4 more
doaj   +1 more source

Accessory Cavitated Uterine Malformation (ACUM): A Case Series

Journal of Clinical Ultrasound, EarlyView.
Accessory cavitated uterine malformation (ACUM) can be misdiagnosed as other uterine pathologies, such as mullerian anomalies, adenomyosis or fibroids. Imaging, particularly gynecological ultrasound plays a fundamental role in identifying this condition.
Luis Felipe Aravena, Roberto Albinagorta, Colomba Spatafore, Arelana Balazs, Yanire Bontemps, Rafael Salazar, Ignacio Brunel, Rodrigo Orozco, Juan Luis Alcázar   +8 more
wiley   +1 more source