Results 71 to 80 of about 479 (137)

Difference and the Liberation of Sufficient Reason

European Journal of Philosophy, EarlyView.
Abstract The Principle of Sufficient Reason (PSR) holds that every event and entity can be explained by a sufficient reason or cause. Philosophers have long struggled with the question of the PSR's compatibility with freedom, for if what occurs or exists follows necessarily from its sufficient reason then it seems it could not have been otherwise ...
Louis Matheou
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Slab buckling as a driver for rapid oscillations in Indian plate motion and subduction rate

Communications Earth & Environment
Plate tectonics is primarily driven by the constant gravitational pull of slabs where oceanic lithosphere sinks into the mantle at subduction zones. Under stable plate boundary configurations, changes in plate motion are then thought to occur gradually ...
Erik van der Wiel, Jakub Pokorný, Hana Čížková, Wim Spakman, Arie P. van den Berg, Douwe J. J. van Hinsbergen   +5 more
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

On the Influence of Pressure, Phase Transitions, and Water on Large‐Scale Seismic Anisotropy Underneath a Subduction Zone

Geochemistry, Geophysics, Geosystems
Seismic anisotropy mainly originates from the crystallographic preferred orientation (CPO) of minerals deformed in the convective mantle flow. While fabric transitions have been previously observed in experiments, their influence on large‐scale ...
John Keith Magali, Christine Thomas, Estelle Elisa Ledoux, Yann Capdeville, Sébastien Merkel   +4 more
doaj   +1 more source

Contrasting Food Web Dynamics Across Oceanographic Boundaries in Subarctic Pelagic Ecosystems

Fisheries Oceanography, EarlyView.
ABSTRACT Understanding the structure of pelagic food webs across multiple trophic levels is critical for elucidating species interactions, energy flow, and anthropogenic impacts on production. This study presents a comprehensive analysis of the eastern North Pacific pelagic food webs, focusing on the Gulf of Alaska (GoA) during late winter of 2019.
Genyffer C. Troina, Evgeny A. Pakhomov, Laurie Weitkamp, Brian P. V. Hunt   +3 more
wiley   +1 more source

Afghanite: A New Silicate‐Matrix Reference Material for In Situ Halogen and Sulfur Microanalysis

Geostandards and Geoanalytical Research, EarlyView.
Key Points A new silicate matrix reference material for in situ chlorine and sulfur determination. Homogeneous across all measured elements. No matrix effects for Cl when calibrating silicate matrices, in contrast to scapolite, which causes systematic Cl overestimation of up to 13%.
Sebastian Stumpf, Thomas Pettke, Johannes Hammerli, Michael A.W. Marks, Andreas Audétat, Jaime D. Barnes, Julia Dietrich, Renée J. Tamblyn   +7 more
wiley   +1 more source

Metamorphic or Igneous Zircon? Classification Through Rare Earth Elements, Machine Learning and Logistic Regression

Journal of Metamorphic Geology, EarlyView.
ABSTRACT Zircon is a common, highly refractory accessory mineral found in sedimentary, igneous and metamorphic rocks that forms through various processes (e.g., magmatic, hydrothermal, metamorphic growth and recrystallization). Trace element compositions of detrital zircon have been widely applied to understanding tectonic processes and continental ...
Jarrod M. Burges, Chris Yakymchuk, Michael P. DiMaio, Timothy C. C. Lui, Anirudh Prabhu, Shaunna M. Morrison   +5 more
wiley   +1 more source

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Slab morphology and deformation beneath Izu-Bonin

Nature Communications, 2019
In the 1000 km long Izu-Bonin subduction zone to the south of Tokyo, the Pacific Plate descends beneath the Philippine Sea Plate. Here the authors use teleseismic double-difference tomography to image the complex morphology of the Izu-Bonin slab ...
Haijiang Zhang, Fan Wang, Robert Myhill, Hao Guo   +3 more
doaj   +1 more source