Results 81 to 90 of about 220,882 (295)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Tracing the influence of the Trans-European Suture Zone into the mantle transition zone

Earth and Planetary Science Letters, 2013
Cratons with their thick lithospheric roots can influence the thermal structure, and thus the convective flow, in the surrounding mantle. As mantle temperatures are hard to measure directly, depth variations in the mantle transition zone (MTZ) discontinuities are often employed as a proxy.
Knapmeyer-Endrun, B., Krüger, F., Legendre, C., Geissler, W.   +3 more
openaire   +3 more sources

Speed structure of the mantle under the Dnieper-Donets Depression and its surroundings. Part I

Геофизический журнал, 2020
The article discusses the high-speed structure of the mantle under the Dnieper-Donets Depression (DDD). The solution obtained by the Taylor approximation of the solution of the three-dimensional seismic tomography problem is used.
T.A. Tsvetkova, I.V. Bugaenko, L.N. Zaets   +2 more
doaj   +1 more source

Methyl on the Bridge: 2‐Methyl Propellane as Precursor for 1,3‐Substituted 2‐Methylated Bicyclo[1.1.1]Pentanes

Chemistry – A European Journal, EarlyView.
The synthesis of 2‐methyl propellane and its conversion to various 1,2‐ and 1,2,3‐di‐ and trisubstituted bicyclopentanes is reported. Abstract Bicyclo[1.1.1]pentanes (BCPs) have emerged as isosteric replacements for mono‐ and para‐substituted benzene rings in medicinal and materials applications, involving substitution at the BCP bridgehead (1,3 ...
Sean R. Verschaeve, Mariana Gomes Manso, Tibo Van Eeckhoorn, Mark E. Light, Bruno Linclau   +4 more
wiley   +1 more source

Research progress on seismic structures of crust and mantle beneath Tien Shan and their geodynamic implications

地球与行星物理论评, 2023
The mechanisms causing the uplifting of the Tien Shan, one of the largest and most active intracontinental orogenic belts on Earth, have been vigorously debated for decades. Seismic investigation is a fundamental tool used for deep structural exploration
Bingfeng Zhang, Xuewei Bao
doaj   +1 more source

Research progress and current status of dynamic wave propagation characteristics in rock mass: A review

Deep Underground Science and Engineering, EarlyView.
This review elucidates the velocity–dispersion–attenuation coupling mechanisms of wave propagation in rock masses, compares six representative models, and reveals how pressure, temperature, mineral composition, and anisotropy jointly control dynamic responses in complex geological media.
Jiajun Shu, Tao Li, Ruiqi Yuan, Yue Li, Bingni Wu, Bo Liu, Zhengding Deng, Galindo Rubén, Fausto Molina‐Gómez   +8 more
wiley   +1 more source

The older ultramafic rocks of Aberdeenshire, similarities to SSZ ophiolites and significance for regional tectonics [abstract] [PDF]

, 2008
It has long been known that there are at least two phases of mafic-ultramafic magmatism in NE Scotland (Read 1919), the well known Younger Gabbro suite and a lesser known ‘Older suite’.
Styles, Michael
core  

The Hudson Bay Lithospheric Experiment (HuBLE) : Insights into Precambrian Plate Tectonics and the Development of Mantle Keels [PDF]

, 2015
The UK component of HuBLE was supported by Natural Environment Research Council (NERC) grant NE/F007337/1, with financial and logistical support from the Geological Survey of Canada, Canada–Nunavut Geoscience Office, SEIS-UK (the seismic node of NERC ...
Bastow, I. D., Darbyshire, F. A., Eaton, D. W., Helffrich, G., Kendall, J.-M., Pawlak, A. E., Snyder, D. B., Thompson, D. A., Wookey, J.   +8 more
core   +2 more sources

Multiphase Tectonic Process With Slab Dynamics in the Northern East China Sea Shelf Basin

Geological Journal, EarlyView.
Megasequence 1 characterised by Palaeocene extension and differential subsidence driven by the rollback of the subducting Izanagi Plate. Megasequence 2 records a kinematic reorganisation of the East Asian margin, transition from a rifting to a compressional regime.
Juhwan Woo, Won‐Ki Kim, Chul Woo Rhee, Seungyeol Lee   +3 more
wiley   +1 more source

Mantle roots of the Emeishan plume: an evaluation based on teleseismic P-wave tomography [PDF]

Solid Earth, 2017
The voluminous magmatism associated with large igneous provinces (LIPs) is commonly correlated to upwelling plumes from the core–mantle boundary (CMB). Here we analyse seismic tomographic data from the Emeishan LIP in southwestern China.
C. He, M. Santosh, M. Santosh
doaj   +1 more source