Results 91 to 100 of about 1,059,053 (303)

An Experience-Connected e-Learning System with a Personalization Mechanism for Learners’ Situations and Preferences [PDF]

open access: yes, 2011
This paper presents an “experience-connected” e- Learning system that facilitates users to learn practical skills of foreign language by associating knowledge and daily-life experiences.
Nagato , KASAKI   +2 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Fundamental motor skills of Czech children at the end of the preschool period

open access: yesActa Gymnica, 2017
Background: Achievement of a sufficient fundamental motor skills (FMS) level by the end of the preschool period is an important premise for the later participation of children in many sports activities.
Jakub Kokštejn   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Evaluation of manual dexterity in early education [PDF]

open access: yes, 2015
Part of the recent research on fine motor skills questions the existence of a general factor of manual dexterity. If this manual dexterity factor is not proved this would affect the suitability of using motor development scales.
Barrio Martínez, Cristina del   +3 more
core  

Challenges in the Automatic Analysis of Students' Diagnostic Reasoning

open access: yes, 2018
Diagnostic reasoning is a key component of many professions. To improve students' diagnostic reasoning skills, educational psychologists analyse and give feedback on epistemic activities used by these students while diagnosing, in particular, hypothesis ...
Bauer, Elisabeth   +7 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Managerial skills: The design of a feedback questionnaire

open access: yesInterdisciplinary Journal of Management Sciences
Formal management development interventions can be costly, with expenses related to acquiring and admin­istering questionnaires. This impedes the implementation of an effective intervention.
Shelley Cook, Renier Steyn
doaj   +1 more source

Home - About - Disclaimer - Privacy