Results 121 to 130 of about 369,419 (282)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Nursing, history, and orthopedics in manuals (1875-1928). [PDF]

open access: yesRev Bras Enferm, 2023
Santos BMOD   +4 more
europepmc   +1 more source

¿Qué tiene de borromea la Retórica de Agostino Valier? [PDF]

open access: yes, 2015
El grupo de las llamadas retóricas borromeas necesita una revisión profunda: el nombre se les dio sin una justificación empírica adecuada, conque puede este grupo estar algo distante de la realidad.
López-Muñoz, Manuel
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Complementary notebook about the study of ideology and policy for health technicians

open access: yesEdumecentro, 2020
Background: in technical science careers that are studied in medical universities, the Study of Ideology and Politics subject is taught with the aim of teaching the historical-logical evolution of the Cuban people, and its example and transcendence for ...
Ana María Sánchez Silva   +3 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Colección de esquemas y fotografías de geografía física [PDF]

open access: yes, 2014
Publicamos en formato electrónico la “Colección de Esquemas y Fotografías de Geografía Física”, la última de la serie de colecciones más antiguas del Fondo Histórico de Diapositivas del Departamento de Geografía de la Universidad de Barcelona.
Castejón, Rosa, Pons Granja, Josep
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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