Results 121 to 130 of about 35,682 (304)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Un manual de urbanidad para los hispanoamericanos

open access: yesKipus: Revista Andina de Letras y Estudios Culturales, 2012
Uno de los libros más leídos por los hispanoamericanos desde mediados del siglo XIX, es el Manuel de urbanidad, de Manuel Antonio Carreño. Hasta hace pocas décadas, fue texto de lectura obligatoria en la mayoría de las escuelas hispanohablantes de ...
Mirla Alcibíades
doaj  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Análisis de algunos manuales escolares lasallistas

open access: yes, 2018
La educación impartida por los lasallistas en Colombia tenía por objeto formar hombres, ilustrados, con conciencia religiosa, moral, responsable y cívica; por ello, catecismo, urbanidad, cortesía, unidad familiar y dominio de sí se favorecen a través de ...
Zapata Muriel, Fernando A
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

[The sign of the cross: a very rare automatism in temporal lobe epilepsy. Two case reports]. [PDF]

open access: yesRev Neurol, 2023
Fernández-Cabrera A   +5 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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