Results 111 to 120 of about 66,426 (248)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Turkish Performance in Exporting Manufactures: A Comparative Structural Analysis [PDF]
This paper considers the prospects for Turkish manufactured exports, now dominated by simple labour-intensive products. The importance to Turkey of diversifying its export base has risen with its EU free trade agreement, where it has advantages in labour-
Sanjaya Lall
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Biennial report of the Vermont State Board of Agriculture, Manufactures and Mining
, 1874 Mode of access ...
Vermont. State Board of Agriculture, Manufacturers and Mining. +1 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
At head of title in this issue.Chiefly statistics."MC."First census taken in 1810 and continued at 10-year intervals (with exception of 1829) through 1899; 5-year intervals through 1919; and biennially through 1939.Issued in parts: Area statistics ...
United States. Bureau of the Census
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Annual report on the statistics of manufactures.
, 1889 1903/04- pub. as a part of the Annual report of the Bureau.In 1890 the "Industrial chronology" became a part of the report and so continued until 1903. 1899/1900-1901/02 being pub. in two parts: pt. I. Industrial chronology; pt. II.
Massachusetts. Bureau of Statistics.
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Механика машин, механизмов и материалов, 2013 Results of modernization of foundry and thermal manufactures RUP "MTZ" are presented. Efficiency of application of the complex technological line, including the equipment for mechanical and vacuum chemical-thermal hardening, manufacturing of details of ...
A.N. Karas +6 more
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