Results 121 to 130 of about 66,426 (248)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 1904 Long view of Palace of Manufactures, with canal and canal boats in ...
Louisiana Purchase Exposition Co. (Saint Louis, Mo.)
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
28 p. ; 20 cm. (8vo)"The Constitution of the Lancaster County Society, for Promoting of Agriculture, Manufactures, and the Useful Arts."--p. [13]-21."An act for the promotion of agriculture, manufactures, and the useful arts."--p. 22-28; "...
Lancaster County Society, for Promoting of Agriculture, Manufactures and the Useful Arts. +1 more
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1958 Census of Manufactures. Arizona.
, 2019 The 1958 Census of Manufactures is the twenty-sixth such census of the United States. The 1958 Census of Manufactures covers all establishments primarily engaged in manufacturing as defined in the revised Standard Industrial Classification Manual, issued
United States Census Bureau; United States Department of Commerce
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
1963 Census of Manufactures. Arizona.
, 2019 The 1963 Census of Manufactures is the twenty-seventh such census of the United States. The 1963 Census of Manufactures covers all establishments primarily engaged in manufacturing as defined in the 1957 edition of the Standard Industrial Classification ...
United States Census Bureau; United States Department of Commerce
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Protocols and Trends in Maintaining the Stability of Orthodontic Treatment Outcomes in Croatia over 10 Years: A Repeated Cross - Sectional Study. [PDF]
Acta Stomatol CroatŽigante M +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source