Results 61 to 70 of about 232,529 (239)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Pakistan: A Case of Premature Deindustrialization?

open access: yesLahore Journal of Economics
While “deindustrialization” is now considered normal for developed countries, recent trends show that many developing countries have seen their share of manufacturing employment peak at far earlier levels of income than in advanced countries.
Naved Hamid, Maha Khan
doaj  

COMPUTER MODELLING OF OBJECTS AND PROCESSES IN FOOD MANUFACTURES

open access: yesАлматы технологиялық университетінің хабаршысы, 2021
In article are shown results of necessity of wide application of mathematical modelling of objects and processes for food manufactures is shown. Main principles of computer modelling, examples of mathematical models of processes and objects are resulted ...
N. S. Zaurbekov   +3 more
doaj  

Is midwest manufacturing at a crossroads? [PDF]

open access: yes
Manufactures ...
Thomas Klier, William A. Testa
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Intercity Trade and the Industrial Diversification of Cities [PDF]

open access: yes
The industrial diversification of cities is explained without imposing linkages among industries. In each of two city-industries, a manufacture is produced competitively as the final good using labor and industry- specific differentiated services ...
Alex Anas, Kai Xiong
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The Profile of Good Hygiene Practice of Catering Service Sector in Samsun

open access: yesTurkish Journal of Agriculture: Food Science and Technology, 2016
Before serving the meals, the managements that operate in the production and distribution of table d’hôte meals, the data related to whether it's appropriate for the food hygiene regulation and the other legal requirements are so insufficient.
Sibel Özçakmak, Osman Gül
doaj   +1 more source

Is manufacturing at a crossroads? [PDF]

open access: yes
Manufactures ; Employment (Economic theory)
Rick Mattoon, William Testa
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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