Results 71 to 80 of about 1,848,254 (281)
Journal of Functional Programming, 2001 This article describes a general framework for designing purely functional datatypes that automatically satisfy given size or structural constraints. Using the framework we develop implementations of different matrix types (for example, square matrices) and implementations of several tree types (for example, Braun trees and 2-3 trees).
openaire +5 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEATURES OF THE DEVELOPMENT OF NEOPLASMS AMONG CHEMICAL WORKERS
Кубанский научный медицинский вестник, 2017 Aim. To study the impact of work environment and occupational factors on the development of neoplasms in chemical workers of the Republic of Bashkortostan.Material and Methods.
E. T. VALEYEVA +4 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
India’s Leather and Manufactures Export in the Scenario of WTO: An Analysis Trend and Structural Shift [PDF]
Managing Global Transitions, 2013 Trade is considered as the engine of growth. For a developing country like India trade plays an important role for achieving the target of sustainable development.
Shrabanti Maity
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
RIHA JournalThis essay locates a late 19th-century category of objects variously named as 'industrial' or 'decorative arts' within the specifically imperial institutional circuit of the World Exhibitions. Taking up a segment of the World Exhibitions of the 1880s, it
Tapati Guha-Thakurta
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Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source