Results 61 to 70 of about 469,015 (246)
International Comparison of High-Technology Manufacturing and Knowledge-Intensive Services in the EU
Economics and Business, 2015 High-technology industries that apply the most advanced and cutting edge technologies are frequently analysed as an opposite to low-technology industries.
Auziņa-Emsiņa Astra
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Rancang Bangun Mesin CNC 2 Sumbu
Metal: Jurnal Sistem Mekanik dan Termal, 2017 Nowadays, high accuracy and precision of products have become a major requirement by the manufacturer. It can only be achieved by using a controlled machine such as CNC machine.
Firman Ridwan, Arif Novriheldi
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Micro/Nano Manufacturing [PDF]
Micromachines, 2017 Micro- and nano-scale manufacturing has been the subject of an increasing amount of interest and research effort worldwide in both academia and industry over the past 10 years.[...]
openaire +4 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Applied SciencesConventional processes require a mould for the manufacture of each test product, which often results in high costs but is ideal for large series of products.
Radu Torpan, Sebastian-Marian Zaharia
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Journal of Functional Programming, 2001 This article describes a general framework for designing purely functional datatypes that automatically satisfy given size or structural constraints. Using the framework we develop implementations of different matrix types (for example, square matrices) and implementations of several tree types (for example, Braun trees and 2-3 trees).
openaire +5 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source