Results 51 to 60 of about 87,767 (354)

"Implementing Green Manufacturing at Sewing Room in Medium Garment Factories Using Lean six Sigma"

Journal of Architecture, Art & Humanistic Science, 2018
Green Manufacturing is the renewal of production processes and the creation of environmentally friendly processes, in this paper we define "Green Manufacturing" as reducing defects in the medium garment factories through the re-evaluation of all stages ...
Ahmed Al Barbary
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Defects, Process Parameters and Signatures for Online Monitoring and Control in Powder-Based Additive Manufacturing

, 2017
Additive Manufacturing (AM) is a process that is based on manufacturing parts layer by layer in order to avoid any geometric limitation in terms of creating the desired design.
El-Mounayri, Hazim, Ehsan Malekipour, Malekipour, Ehsan, Hazim El-Mounayri   +3 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MANUFACTURING DEFECTS OF TABLETS - A REVIEW

Journal of Drug Delivery and Therapeutics, 2013
Tablet defects can come from any of the unit operation upstream and from the tablet press. The raw materials may be of poor quality or do not meet specification, causing excessive fines that lead to a host of defects. The formulation may be the source of defects if the material do not compress well or the processing step specified within the ...
Abhinav Singh Rana, S L Hari Kumar
openaire   +1 more source

A Hybrid CNN-SVM Algorithm for Detecting Manufacturing Defects

IEEE Access
In complex industrial manufacturing processes, various defects may occur in products because of the poor quality of the equipment, materials, and human factors.
Betul Karakas, Sinem Kulluk
doaj   +1 more source

Review of Data-driven Decision Support Systems and Methodologies for the Diagnosis of Casting Defects [PDF]

Archives of Foundry Engineering
The concept of 'Industry 4.0' has introduced great dynamism into production environments, making them more integrated, connected and capable of generating large volumes of data.
A. Burzyńska
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Controlling process instability for defect lean metal additive manufacturing

Nature Communications, 2022
Defects induced by process instabilities in metal additive manufacturing limit its applications. Here, the authors report controlling laser-powder bed interaction instabilities by nanoparticles leads to defect lean metal additive manufacturing.
Minglei Qu, Qilin Guo, Luis I. Escano, Ali Nabaa, S. Mohammad H. Hojjatzadeh, Zachary A. Young, Lianyi Chen   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source