Results 1 to 10 of about 1,685,969 (303)

Epidemiology of birth defects based on a birth defects surveillance system in southwestern China and the associated risk factors

Frontiers in Pediatrics, 2023
BackgroundBirth defects (BDs) are associated with many potential risk factors, and its causes are complex.ObjectivesThis study aimed to explore the epidemiological characteristics of BDs in Guangxi of China and the associated risk factors of BDs ...
Zhenren Peng, Zhenren Peng, Zhenren Peng, Zhenren Peng, Jie Wei, Jie Wei, Jie Wei, Jie Wei, Biyan Chen, Biyan Chen, Biyan Chen, Biyan Chen, Xiuning Huang, Xiuning Huang, Xiuning Huang, Xiuning Huang, Pengshu Song, Pengshu Song, Pengshu Song, Pengshu Song, Lifang Liang, Lifang Liang, Lifang Liang, Lifang Liang, Jiajia He, Jiajia He, Jiajia He, Jiajia He, Baoying Feng, Baoying Feng, Baoying Feng, Baoying Feng, Ting Que, Ting Que, Ting Que, Ting Que, Jie Qin, Jie Qin, Jie Qin, Jie Qin, Yu'an Xie, Yu'an Xie, Yu'an Xie, Yu'an Xie, Xiaoxia Qiu, Xiaoxia Qiu, Xiaoxia Qiu, Xiaoxia Qiu, Hongwei Wei, Hongwei Wei, Hongwei Wei, Hongwei Wei, Sheng He, Sheng He, Sheng He, Sheng He   +55 more
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Resveratrol’s neural protective effects for the injured embryoid body and cerebral organoid

BMC Pharmacology and Toxicology, 2022
Objective Resveratrol (RSV) is a polyphenol compound found in grapes, veratrum and other plants. It has been reported that RSV has anti-inflammatory, anti-oxidant, anti-cancer and other pharmacological effects.
Yanli Wang, Tingting Wei, Qiang Wang, Chaonan Zhang, Keyan Li, Jinbo Deng   +5 more
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Identification of a novel compound heterozygous SMG9 variants in a Chinese family with heart and brain malformation syndrome using whole exome sequencing

BMC Medical Genomics, 2022
SMG9-deficiency syndrome, also known as heart and brain malformation syndrome, is a very rare congenital genetic disorder mainly characterized by brain, heart, and growth and developmental abnormalities.
Qi Yang, Zailong Qin, Qinle Zhang, Shang Yi, Sheng Yi, Jingsi Luo   +5 more
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Novel compound heterozygous variants in the RPL3L gene causing dilated cardiomyopathy type-2D: a case report and literature review

BMC Medical Genomics, 2023
Background Dilated cardiomyopathy type-2D (CMD2D) is a rare heart disease causing a severe cardiomyopathy with neonatal onset and rapid progression to cardiac decompensation and death in untreated patients.
Qi Yang, Qiang Zhang, Zailong Qin, Shujie Zhang, Sheng Yi, Shang Yi, Qinle Zhang, Jingsi Luo   +7 more
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Exploring the mechanism of physcion-1-O-β-D-monoglucoside against acute lymphoblastic leukaemia based on network pharmacology and experimental validation

Heliyon, 2023
Objective: To explore the mechanism of PG against acute lymphoblastic leukaemia (ALL) by network pharmacology and experimental verification in vitro. Methods: First, the biological activity of PG against B-ALL was determined by CCK-8 and flow cytometry ...
Jing Liu, Yan Yang, Yan Zeng, Xiang Qin, Ling Guo, Wenjun Liu   +5 more
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Exploring the pharmacological mechanisms of Shuanghuanglian against T-cell acute lymphoblastic leukaemia through network pharmacology combined with molecular docking and experimental validation

Pharmaceutical Biology, 2023
Context Due to the poor prognosis of T-cell acute lymphoblastic leukaemia (T-ALL), there is an urgent need to identify safer and more cost-effective drugs.Objective This study evaluated the antitumour activity of Shuanghuanglian (SHL) on T-ALL cells and ...
You Yang, Yan Yang, Yunfu Shen, Jing Liu, Yan Zeng, Chengming Wei, Chunyan Liu, Yansha Pan, Qulian Guo, Fangfang Zhong, Ling Guo, Wenjun Liu   +11 more
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Case Report: Christianson Syndrome Caused by SLC9A6 Mutation: From Case to Genotype-Phenotype Analysis

Frontiers in Genetics, 2021
Christianson syndrome (CS) is an X-linked neurodevelopmental syndrome characterized by microcephaly, epilepsy, ataxia, and severe generalized developmental delay.
Yueyun Lan, Yueyun Lan, Sheng Yi, Sheng Yi, Mengting Li, Mengting Li, Jinqiu Wang, Qi Yang, Qi Yang, Shang Yi, Shang Yi, Fei Chen, Fei Chen, Limei Huang, Limei Huang, Yiyan Ruan, Yiping Shen, Yiping Shen, Yiping Shen, Jingsi Luo, Jingsi Luo, Zailong Qin, Zailong Qin   +22 more
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Changes in prevalence and perinatal outcomes of congenital hydrocephalus among Chinese newborns: a retrospective analysis based on the hospital-based birth defects surveillance system

BMC Pregnancy and Childbirth, 2017
Background Little is known about the epidemiology of congenital hydrocephalus (CH) in China. This study aimed to depict recent changes in CH prevalence and perinatal outcomes of the affected newborns.
Ling Yi, Chaomin Wan, Changfei Deng, Xiaohong Li, Kui Deng, Yi Mu, Jun Zhu, Qi Li, Yanping Wang, Li Dai   +9 more
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Clinical exome sequencing identifies novel CREBBP variants in 18 Chinese Rubinstein–Taybi Syndrome kids with high frequency of polydactyly

Molecular Genetics & Genomic Medicine, 2019
Background Rubinstein–Taybi syndrome (RSTS) is a rare genetic disease characterized by broad thumbs and halluces, facial dysmorphisms, short stature, and intellectual disability.
Sha Yu, Bingbing Wu, Yanyan Qian, Ping Zhang, Yulan Lu, Xinran Dong, Qing Wang, Xuemei Zhao, Renchao Liu, Wenhao Zhou, Huijun Wang   +10 more
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Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

Cardiology Journal, 2020
BACKGROUND: Acute kidney injury (AKI) is one of the serious postoperative complications in patients undergoing heart valve surgery. The aim of the present study was to identify selected biomarkers to predict AKI requiring renal replacement.
Piotr Duchnowski, Tomasz Hryniewiecki, Mariusz Kuśmierczyk, Piotr Szymański   +3 more
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