Results 11 to 20 of about 1,071,201 (269)

Exploring the mechanism of physcion-1-O-β-D-monoglucoside against acute lymphoblastic leukaemia based on network pharmacology and experimental validation

Heliyon, 2023
Objective: To explore the mechanism of PG against acute lymphoblastic leukaemia (ALL) by network pharmacology and experimental verification in vitro. Methods: First, the biological activity of PG against B-ALL was determined by CCK-8 and flow cytometry ...
Jing Liu, Yan Yang, Yan Zeng, Xiang Qin, Ling Guo, Wenjun Liu   +5 more
doaj   +1 more source

Novel compound heterozygous variants in the RPL3L gene causing dilated cardiomyopathy type-2D: a case report and literature review

BMC Medical Genomics, 2023
Background Dilated cardiomyopathy type-2D (CMD2D) is a rare heart disease causing a severe cardiomyopathy with neonatal onset and rapid progression to cardiac decompensation and death in untreated patients.
Qi Yang, Qiang Zhang, Zailong Qin, Shujie Zhang, Sheng Yi, Shang Yi, Qinle Zhang, Jingsi Luo   +7 more
doaj   +1 more source

Exploring the pharmacological mechanisms of Shuanghuanglian against T-cell acute lymphoblastic leukaemia through network pharmacology combined with molecular docking and experimental validation

Pharmaceutical Biology, 2023
Context Due to the poor prognosis of T-cell acute lymphoblastic leukaemia (T-ALL), there is an urgent need to identify safer and more cost-effective drugs.Objective This study evaluated the antitumour activity of Shuanghuanglian (SHL) on T-ALL cells and ...
You Yang, Yan Yang, Yunfu Shen, Jing Liu, Yan Zeng, Chengming Wei, Chunyan Liu, Yansha Pan, Qulian Guo, Fangfang Zhong, Ling Guo, Wenjun Liu   +11 more
doaj   +1 more source

Case Report: Christianson Syndrome Caused by SLC9A6 Mutation: From Case to Genotype-Phenotype Analysis

Frontiers in Genetics, 2021
Christianson syndrome (CS) is an X-linked neurodevelopmental syndrome characterized by microcephaly, epilepsy, ataxia, and severe generalized developmental delay.
Yueyun Lan, Yueyun Lan, Sheng Yi, Sheng Yi, Mengting Li, Mengting Li, Jinqiu Wang, Qi Yang, Qi Yang, Shang Yi, Shang Yi, Fei Chen, Fei Chen, Limei Huang, Limei Huang, Yiyan Ruan, Yiping Shen, Yiping Shen, Yiping Shen, Jingsi Luo, Jingsi Luo, Zailong Qin, Zailong Qin   +22 more
doaj   +1 more source

Defects and defect engineering in Soft Matter

Soft Matter, 2020
Defect engineering is a success story in crystalline hard matter; this review summarizes its parallels in amorphous soft matter.
Amir Jangizehi, Friederike Schmid, Pol Besenius, Kurt Kremer, Sebastian Seiffert   +4 more
openaire   +4 more sources

Changes in prevalence and perinatal outcomes of congenital hydrocephalus among Chinese newborns: a retrospective analysis based on the hospital-based birth defects surveillance system

BMC Pregnancy and Childbirth, 2017
Background Little is known about the epidemiology of congenital hydrocephalus (CH) in China. This study aimed to depict recent changes in CH prevalence and perinatal outcomes of the affected newborns.
Ling Yi, Chaomin Wan, Changfei Deng, Xiaohong Li, Kui Deng, Yi Mu, Jun Zhu, Qi Li, Yanping Wang, Li Dai   +9 more
doaj   +1 more source

Semilocal defects [PDF]

Physical Review D, 1992
I analyze the interplay of gauge and global symmetries in the theory of topological defects. In a two-dimensional model in which both gauge symmetries and {\it exact} global symmetries are spontaneously broken, stable vortices may fail to exist even though magnetic flux is topologically conserved.
openaire   +4 more sources

Defects of algebraic function fields, completion defects and defect quotients [PDF]

, 2014
The {\it defect} (also called {\it ramification deficiency}) of valued field extensions is a major stumbling block in deep open problems of valuation theory in positive characteristic. For a detailed analysis, we define and investigate two weaker notions of defect: the {\it completion defect} and the {\it defect quotient}.
Kuhlmann, Franz-Viktor, Naseem, Asim
openaire   +2 more sources

Clinical exome sequencing identifies novel CREBBP variants in 18 Chinese Rubinstein–Taybi Syndrome kids with high frequency of polydactyly

Molecular Genetics & Genomic Medicine, 2019
Background Rubinstein–Taybi syndrome (RSTS) is a rare genetic disease characterized by broad thumbs and halluces, facial dysmorphisms, short stature, and intellectual disability.
Sha Yu, Bingbing Wu, Yanyan Qian, Ping Zhang, Yulan Lu, Xinran Dong, Qing Wang, Xuemei Zhao, Renchao Liu, Wenhao Zhou, Huijun Wang   +10 more
doaj   +1 more source

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

Cardiology Journal, 2020
BACKGROUND: Acute kidney injury (AKI) is one of the serious postoperative complications in patients undergoing heart valve surgery. The aim of the present study was to identify selected biomarkers to predict AKI requiring renal replacement.
Piotr Duchnowski, Tomasz Hryniewiecki, Mariusz Kuśmierczyk, Piotr Szymański   +3 more
doaj   +1 more source