Results 91 to 100 of about 5,834,037 (252)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Creating a sustaining value engineering function within worldwide manufacturing [PDF]

, 2008
Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering; in conjunction with the Leaders for Manufacturing Program at MIT, 2008.Includes ...
Thome, James P
core  

Mission impossible through Extreme Manufacturing: breaking through the constraints of time and space for humanity

International Journal of Extreme Manufacturing
The ultimate objective of manufacturing is to construct a universal tool system capable of systematically overcoming the spatiotemporal constraints facing humanity. In this context, Extreme Manufacturing (EM) has emerged.
Chaofan He, Huayong Yang, Yong He
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Proposing a Model for Evaluating Gate Valve Cover Manufacturing Methods by Value Engineering and Data Envelopment Analysis Approaches with aCase Study in Petro Tajhiz-e-Sepahan Company

International Journal of Industrial Engineering and Production Research, 2015
This research aims at presenting a consolidated model of data envelopment analysis (DEA) technique and value engineering to select the best manufacturing methods for gate valve covers and ranking the methods using TOPSIS.To do so, efficiency evaluation ...
mahdi karbasian, mohammad farahmand, mohammad ziaei   +2 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Development of a manufacturing engineering system for the motor industry : executive summary [PDF]

Manufacturing Engineering is concerned with converting a product specification into the most appropriate method of manufacture to produce the product to the correct cost and quality.
Allchurch, M. J.
core  

Product–process interface for manufacturing data management as a support for DFM and virtual manufacturing [PDF]

, 2008
This research work was supported by SNECMA as part of the MAIA ( http://www.le-webmag.com/article.php3?id_ article=2&lang=) project, the Region Champagne-Ardennes and Sisson Lehmann of the Wheelabrator group.In order to tackle a continuous improvement of
Jawhar Elgueder, Lionel Roucoules, El Gueder, Jawhar, ROUCOULES, Lionel, COCHENNEC, Florent, ROUHAUD, Emmanuelle, Florent Cochennec, Emmanuelle Rouhaud, ELGUEDER, Jawhar   +8 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

BUSINESS MODEL CANVAS AS AN ANALYTICAL TOOL FOR THE EVALUATION OF COMPANIES: CASE STUDY FOR THE AUDIOVISUAL INDUSTRY IN BOGOTA, COLOMBIA

South African Journal of Industrial Engineering, 2019
The paper discusses analytical applications of the business model canvas (BMC) formulated by Osterwalder & Pigneur [1]. From this model, a methodological tool was devised and used as part of an academic research project, in which the categories (blocks ...
Ruiz-Ramirez, Jessica Alejandra , Reyes-Cancino, Diego Felipe , Arenas-Castro, Carlos Julio   +2 more
doaj   +1 more source