Results 71 to 80 of about 1,282,960 (310)
, 2014 Designing complex engineering systems, such as an aircraft or an aero-engine, is immensely challenging. Formal Systems Engineering (SE) practices are widely used in the aerospace industry throughout the overall design process to minimise the overall ...
Bertoni, M. +3 more
core +3 more sources
On a Service-Oriented Approach for an Engineering Knowledge Desktop [PDF]
, 2006 Increasingly, manufacturing companies are shifting their focus from selling products to providing services. As a result, when designing new products, engineers must increasingly consider the life cycle costs in addition to any design requirements.
Crowder, Richard M +2 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Web-based CBR (case-based reasoning) as a tool with the application to tooling selection [PDF]
, 2005 Over the past few years, manufacturing companies have had to deal with an increasing demand for feature-rich products at low costs. The pressures exerted on their existing manufacturing processes have lead manufacturers to investigate internet-based ...
Aamodt +8 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Effect of advanced manufacturing technology, concurrent engineering of product design, and supply chain performance of manufacturing companies [PDF]
, 2015 As competition shifts away between competitors to supply chains, simultaneous sharing of technical expertise on product design is key to manufacturing success.
Abd Rahman, Azmawani +2 more
core +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
A Comprehensive Decision-Making Approach for Strategic Product Module Planning in Mass Customization
MathematicsThis paper explores the integrated optimization of complex coupled industrial manufacturing systems and production strategies based on user customization needs. Two optimization metrics are considered: one is whether the production process of engineering
Shuo-Fang Liu +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Additive Manufacturing of Hydrogels in Tissue Engineering [PDF]
Journal of Chemistry LettersSystematically review the development of 3D printing, describe the area of 3D printing hydrogel research, and describe the development of 3D printing hydrogel.
Md. Shyeed +5 more
doaj +1 more source