Results 71 to 80 of about 216,200 (264)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Developing a Virtual Laboratory Framework Based on the Lean Approach in Engineering Education: A Response to Industry 4.0 Skills

Engineering Proceedings
The rapid advancement of digital technologies, referred to as Industry 4.0, has profoundly transformed the manufacturing landscape, necessitating a reevaluation of engineering education.
Khadija Talbi, Zineb Ait Haddouchane, Soumia Bakkali, Souad Ajana   +3 more
doaj   +1 more source

Bibliometric analysis of model-based systems engineering in advanced manufacturing [PDF]

Journal of Intelligent Manufacturing and Special Equipment
Purpose – Model-based systems engineering (MBSE) is an important approach for the transforming process from “document-centered” to “model centered” systems engineering mode in equipment development, which can effectively shorten the equipment development
Jinzhi Lu, Yihui Gong, Guoxin Wang, Yan Yan   +3 more
doaj   +1 more source

Special Issue of the Manufacturing Engineering Society 2021 (SIMES-2021). [PDF]

Materials (Basel), 2022
Rodríguez-Prieto Á, Trujillo FJ.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mission impossible through Extreme Manufacturing: breaking through the constraints of time and space for humanity

International Journal of Extreme Manufacturing
The ultimate objective of manufacturing is to construct a universal tool system capable of systematically overcoming the spatiotemporal constraints facing humanity. In this context, Extreme Manufacturing (EM) has emerged.
Chaofan He, Huayong Yang, Yong He
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Proposing a Model for Evaluating Gate Valve Cover Manufacturing Methods by Value Engineering and Data Envelopment Analysis Approaches with aCase Study in Petro Tajhiz-e-Sepahan Company

International Journal of Industrial Engineering and Production Research, 2015
This research aims at presenting a consolidated model of data envelopment analysis (DEA) technique and value engineering to select the best manufacturing methods for gate valve covers and ranking the methods using TOPSIS.To do so, efficiency evaluation ...
mahdi karbasian, mohammad farahmand, mohammad ziaei   +2 more
doaj  

The Hirsch index in manufacturing and Quality engineering

Quality and Reliability Engineering International, 2009
AbstractThe Hirsch index (h) is a recent bibliometric indicator for assessing the research output of scientists. Its most remarkable characteristics are immediate intuitive meaning, effective synthesis and easy calculation. With few modifications, the use of this indicator can be profitably extended to other fields beyond bibliometrics.
FRANCESCHINI, FIORENZO, MAISANO, DOMENICO AUGUSTO FRANCESCO   +1 more
openaire   +2 more sources