Results 51 to 60 of about 1,282,960 (310)

How Can We Instill a Culture of Accountability in Employees in Manufacturing Companies? [PDF]

open access: yes, 2015
For our engineering and manufacturing site, frequent leadership, ownership, and operating model changes have led to difficulty instilling a culture of ownership and accountability in employees.
Kovack, Kasey
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Engineering Workflow: The Process in Product Data Technology [PDF]

open access: yes, 2000
The prevailing paradigm for enterprises in the new decade is undoubtedly speed. This enterprise view is driven by the availability of e-business technology that enables new forms of collaboration between companies.
Bijwaard, D.J.A.   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Manufacturing Systems Operations and Engineering

open access: yesApplied Sciences
Although the issues of design, organization, and management of industrial systems have been known in the literature for many years, the beginning of the 21st century, as a consequence of market changes and unprecedented technological development ...
Arkadiusz Gola   +2 more
doaj   +1 more source

The development of the application of artificial intelligence in production engineering: One glance [PDF]

open access: yesTehnika
Artificial intelligence (AI) has today become the most important element of the Industry 4.0 model in application, and on the way to building a smart factory.
Majstorović Vidosav D.
doaj   +1 more source

Pictorial display of materials and processes aids in fabricating complex assemblies [PDF]

open access: yes, 1971
Method uses assembly consisting of single pictorial display showing cutaway view of assembly, subassemblies identified by name and materials, and processes identified by both specification and commercial design.
Ehret, R. M., Fawkes, G. J.
core   +1 more source

Engineering Meets Manufacturing [PDF]

open access: yesMechanical Engineering, 2007
This article discusses the future of software that links engineering and manufacturing. Companies are seeking a natural link between engineering and manufacturing, even if some aspects of it may be restricted. According to experts, giving manufacturers direct access to that design information would help them isolate potential manufacturing problems ...
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

SLASSY—An Assistance System for Performing Design for Manufacturing in Sheet-Bulk Metal Forming: Architecture and Self-Learning Aspects

open access: yesAI, 2021
Substantial efforts have been made to integrate manufacturing- and design-relevant knowledge into product development processes. A common approach is to provide the relevant knowledge to the design engineers using a knowledge-based system (KBS) that, in ...
Christopher Sauer   +4 more
doaj   +1 more source

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