Results 51 to 60 of about 5,834,037 (252)
Knowledge engineering in manufacturing
, 2022 S.303-309Expert systems are gaining in development and usage throughout the world. Expert systems applications are particularly growing in number in engineering and manufacturing.
Spur, G., Specht, D.
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iScienceSummary: Electric arc furnace (EAF) steelmaking underpins China’s low-carbon steel transition, while uneven regional resources and energy conditions greatly constrain its low-carbon development.
Jialin Shen +9 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Manufacturing knowledge verification in design support systems [PDF]
, 2008 This paper identifies the need for a verification methodology for manufacturing knowledge in design support systems; and proposes a suitable methodology based on the concept of ontological commitment and the PSL ontology (ISO/CD18629).
Robert Young +34 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Tutorials for Integrating CAD/CAM in Engineering Curricula
Education Sciences, 2018 This article addresses the issue of educating engineering students with the knowledge and skills of Computer-Aided Design and Manufacturing (CAD/CAM). In particular, three carefully designed tutorials—cutting tool offsetting, tool-path generation ...
AMM Sharif Ullah, Khalifa H. Harib
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Manufacturing Systems Operations and Engineering
Applied SciencesAlthough the issues of design, organization, and management of industrial systems have been known in the literature for many years, the beginning of the 21st century, as a consequence of market changes and unprecedented technological development ...
Arkadiusz Gola +2 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Chaos Engineering for Resilient Manufacturing: A Digital Twin Perspective
SystemsChaos engineering is currently being used by some of the largest software companies in the world to develop IT systems that can withstand turbulent production conditions. This study presents an approach for applying chaos engineering across manufacturing
Tim van Erp +4 more
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