Results 41 to 50 of about 216,200 (264)

Drivers of Automation and Consequences for Jobs in Engineering Services: An Agent-Based Modelling Approach

Frontiers in Robotics and AI, 2021
New technology is of little use if it is not adopted, and surveys show that less than 10% of firms use Artificial Intelligence. This paper studies the uptake of AI-driven automation and its impact on employment, using a dynamic agent-based model (ABM ...
Hildegunn Kyvik Nordås, Hildegunn Kyvik Nordås, Franziska Klügl   +2 more
doaj   +1 more source

Management of the engineering data for manufacturing

Journal of Engineering Research, 2020
All departments in a business work separately, but for the same purpose.In this article, a system that allows not only the mechanical design department but also the manufacturing, storage, process planning, quality control, electrical design, purchasing departments, etc. to have access to the required information has been developed.
Gurcan Atakok, Mufit Cun
openaire   +4 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Manufacturing Systems Operations and Engineering

Applied Sciences
Although the issues of design, organization, and management of industrial systems have been known in the literature for many years, the beginning of the 21st century, as a consequence of market changes and unprecedented technological development ...
Arkadiusz Gola, Chandima Ratnayake, Martin Krajčovič   +2 more
doaj   +1 more source

Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation

Frontiers in Bioengineering and Biotechnology, 2022
While the soft mechanics and tunable cell interactions facilitated by hydrogels have attracted significant interest in the development of functional hydrogel-based tissue engineering scaffolds, translating the many positive results observed in the lab ...
Fei Xu, Chloe Dawson, Makenzie Lamb, Eva Mueller, Evan Stefanek, Evan Stefanek, Mohsen Akbari, Mohsen Akbari, Mohsen Akbari, Todd Hoare   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The development of the application of artificial intelligence in production engineering: One glance [PDF]

Tehnika
Artificial intelligence (AI) has today become the most important element of the Industry 4.0 model in application, and on the way to building a smart factory.
Majstorović Vidosav D.
doaj   +1 more source

Engineering Experiments in Manufacturing Education

Journal of Robotics and Mechatronics, 2011
This paper deals with engineering experiments in manufacturing education. In the Department of Electronic Control Engineering of Nagaoka National College of Technology, an engineering experiment in manufacturing education, “electronic circuit designs and manufacturing,” has been carried out since 2003. The theme of this experiment has been changed from
Hiroshi Satoh, Shigehiro Toyama, Nobuo Ogawa, Mikio Umeda, Akira Takahashi, Makoto Usui, Hisaya Oyanagi   +6 more
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source