Results 41 to 50 of about 5,834,037 (252)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Energy efficient manufacturing from machine tools to manufacturing systems [PDF]

, 2013
46th CIRP Conference on Manufacturing Systems, 29-31st May 2013, Sesimbra, PortugalEnergy efficiency is one of the key drivers for sustainability. Within manufacturing environments, energy efficiency importance has grown, and it is now considered among ...
Salonitis, Konstantinos, Ball, Peter, Ball, Peter D.   +2 more
core   +1 more source

Research on the Driving Mechanism of the Innovation Ecosystem in China’s Marine Engineering Equipment Manufacturing Industry

Systems
To enhance the strength of the marine economy, safeguard marine rights and interests, and promote the sustainable development of marine resources, China is actively building an innovation ecosystem in the marine engineering equipment manufacturing ...
Tuochen Li, Xinyu Zhou
doaj   +1 more source

A Potential Research Area Under Shadow In Engineering: Agricultural Machinery Design and Manufacturing

ISPEC Journal of Agricultural Sciences, 2020
As a branch of the global machinery industry, the agricultural (farm) machinery design and manufacturing or agricultural engineering industry has become one of the most important industries to be supported and focussed on in the era of hunger threats ...
H. Kursat CELIK, Allan E. W. RENNIE, Ibrahim AKINCI   +2 more
doaj   +1 more source

CURRENT SURVEYING METHODS FOR THE INTEGRATION OF ADDITIVE MANUFACTURING IN THE CONSTRUCTION PROCESS [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2020
The Technical University of Braunschweig (Brunswick) and Technical University of Munich were successful to establish a Collaborative Research Centre called “Additive Manufacturing in Construction (AMC) – The Challenge of Large Scale” starting from 2020 ...
M. Maboudi, M. Gerke, N. Hack, L. Brohmann, P. Schwerdtner, G. Placzek   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The emergence of sustainable manufacturing practices [PDF]

, 2011
Sustainable manufacturing appears to be a rapidly developing field and it would be expected that there is a growing body of knowledge in this area. Initial examination of the literature shows evidence of sustainable work in the areas of product design ...
Mbaye, Fatou, Mbaye, F, M. Despeisse, Levers, Andy, Ball, Peter D., Despeisse, M, A. Levers, Ball, Peter David, Despeisse, Melanie, ,, Despeisse, Mélanie,, Levers, Andrew, Levers, A., Despeisse, M\ue9lanie, D. Ball, Peter, P.D. Ball, Mbaye, F., F. Mbaye, Levers, Andy,, Mbaye, Fatou,, Ball, PD, Levers, A, D. Ball, Peter,   +22 more
core   +1 more source

Strategic Production Process Design with Additive Manufacturing in a Make-to-stock Environment

, 2023
With the development and gradual maturity of additive manufacturing (AM) over the years, AM has reached a stage where implementation into a conventional production system becomes possible.
Yen Ting Ng, Seung Ki Moon, Ng, Yen Ting, Manel Lopez, Lopez, Manet, Ping Chong Chua, Moon, Seung Ki, Chua, Ping Chong   +7 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source