Results 61 to 70 of about 5,834,037 (252)

The development of the application of artificial intelligence in production engineering: One glance [PDF]

Tehnika
Artificial intelligence (AI) has today become the most important element of the Industry 4.0 model in application, and on the way to building a smart factory.
Majstorović Vidosav D.
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Lean-Driven Sustainable Engineering Enhanced by TRIZ: A Conceptual Approach to Waste Elimination in Manufacturing System Laboratory

Journal of Applied Engineering and Technological Science
Manufacturing system laboratories are essential in engineering education, however, existing laboratory-scale equipment often exhibits long cycle times, high energy consumption, poor ergonomics, and limited integration of sustainability principles.
Uly Amrina, Hendi Herlambang, Galang Persada Nurani Hakim, Irkham Syifaul Qulub, Lutfi Saputro   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Cost engineering for manufacturing: current and future research [PDF]

, 2011
This paper aims to review the current practice in cost engineering, identify the scientific research challenges and suggest future direction of this area research.
E. Shehab (7211669), Cheung, Wai Ming, Erkoyuncu, J. A., Newnes, Linda, Roy, R.,, Wang, Qing, Shehab, E., Baguley, P.,, P. Arundachawat (7211666), P. Baguley, J.A. Erkoyuncu (7211654), F. Elgh (7211651), Shehab, E.,, Wang, Q., Erkoyuncu, John Ahmed, Q. Wang, Cheung, W. M., Xu, Y., Q. Wang (782488), Roy, R., Yee Goh (1256379), Baguley, P., Goh, Yee Mey, Arundachawat, P.,, F. Elgh, Goh, Y.,, Elgh, Fredrik,, Bankole, O.,, R. Roy, Newnes, L.,, Baguley, Paul, Y. Goh, Shehab, Essam, Cheung, W. M.,, E. Shehab, O. Bankole (7211657), Newnes, L., Cheung, W.M., Y. Xu (741407), Erkoyuncu, J.A., Y. Xu, Roy, Rajkumar, O. Bankole, Wang, Q.,, J. A. Erkoyuncu, Goh, Y., R. Roy (2538628), Elgh, F., Arundachawat, Panumas, Bankole, O., Xu, Yuchun,, Linda B. Newnes (7204940), W. M. Cheung, P. Baguley (7211663), Erkoyuncu, John,, Xu, Yuchun, Bankole, Oyetola, L. Newnes, P. Arundachawat, Arundachawat, P., W.M. Cheung (7211660)   +60 more
core   +1 more source

Engineering and Environmental Analysis of Additive Manufacturing in the Food Industry

Engineering Proceedings
In the context of increasing demands for sustainability and individualization in the food industry, additive manufacturing (AM) represents a promising technology with the potential to transform manufacturing processes.
Valentina Nikolova-Alexieva, Katina Valeva, Margarita Terziyska, Hristian Panayotov   +3 more
doaj   +1 more source

Selective Laser Melting: Materials and Applications

Journal of Manufacturing and Materials Processing, 2020
Additive manufacturing (AM) is one of the emerging manufacturing techniques of immense engineering and scientific importance and is regarded as the technique of the future [...]
Konda Gokuldoss Prashanth
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source