Results 61 to 70 of about 1,282,960 (310)

Rapid design of tool-wear condition monitoring systems for turning processes using novelty detection [PDF]

, 2009
Condition monitoring systems of manufacturing processes have been recognised in recent years as one of the key technologies that provide the competitive advantage in many manufacturing environments. It is capable of providing an essential means to reduce
Al-Azmi, A, Al-Habaibeh, A, Redgate, J
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Engineering and Environmental Analysis of Additive Manufacturing in the Food Industry

Engineering Proceedings
In the context of increasing demands for sustainability and individualization in the food industry, additive manufacturing (AM) represents a promising technology with the potential to transform manufacturing processes.
Valentina Nikolova-Alexieva, Katina Valeva, Margarita Terziyska, Hristian Panayotov   +3 more
doaj   +1 more source

Selective Laser Melting: Materials and Applications

Journal of Manufacturing and Materials Processing, 2020
Additive manufacturing (AM) is one of the emerging manufacturing techniques of immense engineering and scientific importance and is regarded as the technique of the future [...]
Konda Gokuldoss Prashanth
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Systematic innovation and the underlying principles behind TRIZ and TOC [PDF]

, 2003
Innovative developments in the design of product and manufacturing systems are often marked by simplicity, at least in retrospect, that has previously been shrouded by restrictive mental models or limited knowledge transfer. These innovative developments
D. Mann, Duguay, R. Stratton, Silveira, Steyn, Warburton   +5 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Sound recordings of leading professors of Spanish Manufacturing Engineering. Analysis of contents. [PDF]

, 2019
ISBN 978-84-09-10387-4"Academic Lives in Industrial Engineering" is one of the different initiatives developed by PATRIF, a Working Group of the Manufacturing Engineering Society (MES) / Sociedad de Ingeniería de Fabricación (SIF).
Claver Gil, Juan, Sebastián Pérez, Miguel Ángel, Sevilla-Hurtado, Lorenzo   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The use of simulated games in an undergraduate course manufacturing processes [PDF]

, 2009
Simulation games bring the real engineering situation into class room. They are ideally suited to situations where the size and cost of some systems cannot be replicated in educational institutions, e.g.
Pather, Selvan, Wang, Hao
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