Results 21 to 30 of about 958,986 (177)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Mechanical Engineering Technology Newsletter 2019 [PDF]

, 2019
Table of Contents Where Racing Will Take Him Irwin Wins Center for Teaching and Learning Instructional Award Five MET Students Inducted into Epsilon Pi Tau Honor Society 2018 and 2019 Scholarship Awards 2018 Bob Mark Business Model Competition Senior ...
Department of Manufacturing and Mechanical Engineering Technology, Michigan Technological University
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Sound recordings of leading professors of Spanish Manufacturing Engineering. Analysis of contents. [PDF]

, 2019
ISBN 978-84-09-10387-4"Academic Lives in Industrial Engineering" is one of the different initiatives developed by PATRIF, a Working Group of the Manufacturing Engineering Society (MES) / Sociedad de Ingeniería de Fabricación (SIF).
Claver Gil, Juan, Sebastián Pérez, Miguel Ángel, Sevilla-Hurtado, Lorenzo   +2 more
core  

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Virtual manufacturing: prediction of work piece geometric quality by considering machine and set-up [PDF]

, 2011
Lien vers la version éditeur: http://www.tandfonline.com/doi/full/10.1080/0951192X.2011.569952#.U4yZIHeqP3UIn the context of concurrent engineering, the design of the parts, the production planning and the manufacturing facility must be considered ...
D'ACUNTO, Alain, DANTAN, Jean-Yves, MARTIN, Patrick   +2 more
core   +7 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Investigation of factors affecting the learning of final year advanced materials and manufacturing students [PDF]

, 2007
An investigation was recently conducted into the delivery of an Advanced Materials and Manufacturing Processes module which was presented to a sub-group of the final year engineering students at Dublin City University (DCU).
Brabazon, Dermot, Looney, Lisa, Naher, Sumsun   +2 more
core  

A Reverse Engineering for Manufacturing approach [PDF]

Computer-Aided Design and Applications, 2014
ABSTRACTDefining a Computer Aided Process Planning (CAPP) model from a physical part is an important issue in product improvement, remanufacturing and quality control. Reverse Engineering (RE) is a process that allows to convert low level geometric information like 3D points cloud to high level information such as CAD model, CAPP model etc. There exist
Ali, Salam, Durupt, Alexandre, Adragna, Pierre-Antoine, BOSCH-MAUCHAND, Magali   +3 more
openaire   +4 more sources