Results 31 to 40 of about 2,775,388 (305)

Benefits of Aeronautical Preform Manufacturing through Arc-Directed Energy Deposition Manufacturing [PDF]

, 2023
Publisher Copyright: © 2023 by the authors.The paper introduces an innovative aerospace component production approach employing Wire Arc Additive Manufacturing (WAAM) technology to fabricate near-finished preforms from Ti6Al4V titanium.
Tomas Ballesteros, Veiga, Fernando, Pedro Ramiro, Fernando Veiga, Suárez, Alfredo, Ramiro, Pedro, Pedro Villanueva, Ballesteros, Tomas, Villanueva, Pedro, Alfredo Suárez   +9 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Meshing Characteristic Analysis of CBR Reducer Considering Tooth Modification and Manufacturing Error

Machines
The China Bearing Reducer (CBR) is a single-stage cycloid reducer with a compact structure, primarily used in high-precision fields such as robotic joints and Computer Numerical Control (CNC) machine tool turntables, where strict requirements for ...
Xiaoxiao Sun, Zhihao Qian, Yaochen Xu, Jiacai Huang   +3 more
doaj   +1 more source

A Precise Manufacturing Method of the Composite Structure-Similar Flutter Model

Advances in Mechanical Engineering, 2014
The composite structure-similar flutter model (ComSSM) not only shows higher structural efficiency but also provides convenience for the purpose of fabrication in the aerodynamic flutter model.
Rui Yang, Shiyong Sun, Wei Qian, Dongming Guo   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Estimate of the Actual Coefficient of Overlap of Spur Gears

Механика машин, механизмов и материалов, 2013
An engineering method of an approximate estimate of the actual coefficient of overlap depending on the load acting in engagement for spur gears of external engagement with the theoretical overlap ratio 1< εTα< 2 is proposed. The method can be used at the
N.N. Ishin , A.M. Goman, A.S. Skorokhodov   +2 more
doaj  

Empirical Evidence of a Long-Run Relationship Between Agriculture and Manufacturing Industry Output in Nigeria

SAGE Open, 2020
This study investigates a long-run relationship between agriculture and manufacturing industry output in Nigeria using annual time series data from 1982 to 2017.
Eze Simpson Osuagwu
doaj   +1 more source

Analisis Faktor-Faktor yang Memengaruhi Output Sektor Industri Pengolahan di Provinsi Jawa Tengah

Tataloka, 2021
Industrial manufacturing sektor has the biggest contribution to regional economic development of Central Java Province but in the last few years the output of industrial sector experienced a slowing down growth.
Selviana Raharjo, Dedi Budiman, Sahara Sahara   +2 more
doaj   +1 more source