Results 41 to 50 of about 2,775,388 (305)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USING THE ANGULAR CYLINDRICAL REFLEKTOR TO ADJAST THE SENSIVITY OF THE ULTRASONIK FLAW DETEKTOR

Литьë и металлургия, 2016
The article analyzes the existing artificial reflectors are used to adjust the sensitivity of the ultrasonic flaw detectors. Noting their shortcomings, mainly related to the accuracy of manufacture.
A. G. Lezhava, A. A. Pivovarchyk, A. S. Traihel   +2 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

On the Numerical Modelling and Error Compensation for General Gough-Stewart Platform

International Journal of Advanced Robotic Systems, 2014
Parallel robots are specially designed to perform high-precision tasks. Nevertheless, manufacturing, assembling and control issues can reduce their capacity to perform adequately. Observing the acquired measurement data with high-precision devices - such
Eusebio Hernandez, Sergio Ivvan Valdez, Eduardo Sanchez   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

High-Precision Calibration of Dual 6-DOF Series-Parallel Robot Actuators for Precision Manufacturing Systems via a Hierarchical Decoupling Multi-Modal Fusion Algorithm

Actuators
Dual 6 degrees of freedom (6-DOF) series-parallel cooperative robot actuators are core execution components in modern intelligent manufacturing systems, which are widely used in high-end manufacturing scenarios such as aerospace precision assembly, laser
Litong Zhang, Haonan Dai, Mingyang Liu, Lizhong Sun   +3 more
doaj   +1 more source

Novel Approach to Manufacture an AUV Propeller by Additive Manufacturing and Error Analysis [PDF]

Applied Sciences, 2019
Autonomous underwater vehicle (AUV) is an unmanned tether-free vehicle which is powered by battery or fuel cell. The weight of the AUV is a major issue to be decided when considering its performance. To manufacture a propeller that is lighter in weight and able to carry the pressure applied to the blades is an involving process.
H. M. T. Khaleed, Irfan Anjum Badruddin, A. N. Saquib, M. F. Addas, Sarfaraz Kamangar, T. M. Yunus Khan   +5 more
openaire   +2 more sources

A Manufacturing Informatics Framework for Manufacturing Sustainability Assessment. In : Re-engineering Manufacturing for Sustainability, Springer [PDF]

, 2013
Manufacturing firms that wish to improve their environmental performance of their product, process, and systems are faced with a complex task because manufacturing systems are very complex and they come in many forms and life expectancies.
ZHAO, Yaoyao Fiona, ANDRIANKAJA, Héry, PERRY, Nicolas   +2 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source