Results 41 to 50 of about 816,445 (307)

Meshing Characteristic Analysis of CBR Reducer Considering Tooth Modification and Manufacturing Error

Machines
The China Bearing Reducer (CBR) is a single-stage cycloid reducer with a compact structure, primarily used in high-precision fields such as robotic joints and Computer Numerical Control (CNC) machine tool turntables, where strict requirements for ...
Xiaoxiao Sun, Zhihao Qian, Yaochen Xu, Jiacai Huang   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Gear tolerancing for simultaneous optimization of transmission error and contact pressure

Results in Engineering, 2021
With electrification of vehicles comes an increasing demand on low noise, which for gears translates to transmission error. In this paper, static transmission error, STE, is found for a large number of manufacturing error combinations belonging to ...
R. Hjelm, A. Ahadi, J. Wahlström
doaj   +1 more source

Closed-loop Identification of an Industrial Extrusion Process [PDF]

, 2017
This paper deals with the challenging problem of closed-loop identification for multivariable chemical processes and particularly the estimation of an open-loop plant model for a lab-scale industrial twin-screw extruder used in a powder coatings ...
Chiuso, Chiuso, Chou, Codrons, Forssel, Gilson, Gudi, Hof, Huang, Jorgensen, Katayama, Katayama, Katayama, Leskens, Lin, Oku, Oku, Pouliquen, Van Den Hof   +18 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

On the Numerical Modelling and Error Compensation for General Gough-Stewart Platform

International Journal of Advanced Robotic Systems, 2014
Parallel robots are specially designed to perform high-precision tasks. Nevertheless, manufacturing, assembling and control issues can reduce their capacity to perform adequately. Observing the acquired measurement data with high-precision devices - such
Eusebio Hernandez, Sergio Ivvan Valdez, Eduardo Sanchez   +2 more
doaj   +1 more source

Demand uncertainty and lot sizing in manufacturing systems: the effects of forecasting errors and mis-specification [PDF]

, 2005
This paper proposes a methodology for examining the effect of demand uncertainty and forecast error on lot sizing methods, unit costs and customer service levels in MRP type manufacturing systems.
Fildes, R A, Kingsman, B G
core  

Analytical models for high performance milling. Part I: cutting forces, structural deformations and tolerance integrity [PDF]

, 2006
Milling is one of the most common manufacturing processes in industry. Despite recent advances in machining technology, productivity in milling is usually reduced due to the process limitations such as high cutting forces and stability.
Budak, Erhan
core   +1 more source

Novel Approach to Manufacture an AUV Propeller by Additive Manufacturing and Error Analysis [PDF]

Applied Sciences, 2019
Autonomous underwater vehicle (AUV) is an unmanned tether-free vehicle which is powered by battery or fuel cell. The weight of the AUV is a major issue to be decided when considering its performance. To manufacture a propeller that is lighter in weight and able to carry the pressure applied to the blades is an involving process.
H. M. T. Khaleed, Irfan Anjum Badruddin, A. N. Saquib, M. F. Addas, Sarfaraz Kamangar, T. M. Yunus Khan   +5 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source