Results 81 to 90 of about 559,594 (297)

Services reform and manufacturing performance : evidence from India [PDF]

open access: yes
The growth of India's manufacturing sector since 1991 has been attributed mostly to trade liberalization and more permissive industrial licensing. This paper demonstrates the significant impact of a neglected factor: India's policy reforms in services ...
Arnold, Jens Matthias   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Health and Safety Issues in Selected Nigerian Medium-Sized Manufacturing Firms

open access: yesThe Indonesian Journal of Occupational Safety and Health
Introduction: Medium-sized firms around the world are confronted with several challenges which have continued to hamper their growth chances. One of these issues is lack of global best practices in health and safety. This issue is pronounced among medium-
James Akinbode   +3 more
doaj   +1 more source

The Effects of Postponed Manufacturing and Product Planning on Inventory Performance:

open access: yesMaketingu Janaru, 2020
Postponement of decision making in manufacturing and product planning has been adopted in many industries. In particular, apparel firms are trying to absorb demand uncertainty and inventory risk through additional manufacturing and planning throughout ...
Sho Yuki
doaj   +1 more source

Strategic Planning Improves Manufacturing Performance [PDF]

open access: yes
A quantitative critique of 28 studies concludes that formal planning is valuable for firms. The results were particularly favorable for manufacturing firms: nine studies found formal planning to be associated with better performance and none found ...
JS Armstrong
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Modern Management: Good for the Environment or Just Hot Air? [PDF]

open access: yes
We use an innovative methodology to measure management practices in over 300 manufacturing firms in the UK. We then match this management data to production and energy usage information for establishments owned by these firms. We find that establishments
Christos Genakos   +3 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Differences in export behavior of services and manufacturing firms in Slovenia

open access: yesEconomic and Business Review, 2011
<p>We provide new comprehensive evidence on similarities and differences in export Behavior of Slovenian manufacturing and services firms by using detailed firm-level panel data for Slovenia.
Tanja Grublješič, Jože P. Damijan
doaj  

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