Results 51 to 60 of about 295,568 (317)

PhysGMM-MoE: A Physics-Aware GMM-Mixture-of-Experts Framework for Small-Sample Engine Fault Classification

Applied Sciences
Accurate engine fault classification with limited labeled data is critical for the safety and reliability of rotating machinery. This task is challenging because operating regimes are time-varying, and key variables must satisfy physical constraints ...
Qingang Xu, Hongwei Wang, Yunhang Wang, Xicong Chen   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Transformer Fault Diagnosis Method Based on SCA-VMD and Improved GoogLeNet

Applied Sciences
Aiming at the influence of the fundamental frequency and its harmonics in transformer vibration signals on fault signals, which cause a low fault identification rate and degradation of classification model performance, a new strategy is proposed for ...
Kezhan Zhang, Wenlei Sun, Yinjun Ba, Zhiyuan Liu   +3 more
doaj   +1 more source

Modeling and Analysis of Industry 4.0 Adoption Challenges in the Manufacturing Industry

, 2022
The manufacturing sector is a fast-growing sector demanded by the increasing population. The adoption of information technology is a boon in the manufacturing industry.
Naif Alsaadi
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Using Petri Nets and 4M1E Identification Resolution for Manufacturing Process Control and Information Tracking: Case Study of Transformer Coil Production

Applied Sciences
To solve the problems of chaotic information management and difficult traceability in the manufacturing process of transformer coils, a traceability and management method oriented towards the manufacturing process of transformer coils has been proposed ...
Xuedong Zhang, Wenlei Sun, Shijie Song, Chen Lu   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A novel method for intelligent operation and maintenance of transformers using deep visual large model DETR + X and digital twin

Scientific Reports
To achieve real-time monitoring and intelligent maintenance of transformers, a framework based on deep vision and digital twin has been developed. An enhanced visual detection model, DETR + X, is proposed, implementing multidimensional sample data ...
Xuedong Zhang, Wenlei Sun, Ke Chen, Shijie Song   +3 more
doaj   +1 more source

Construction and Validation of a Digital Twin-Driven Virtual-Reality Fusion Control Platform for Industrial Robots

Sensors
Traditional industrial robot programming methods often pose high usage thresholds due to their inherent complexity and lack of standardization. Manufacturers typically employ proprietary programming languages or user interfaces, resulting in steep ...
Wenxuan Chang, Wenlei Sun, Pinghui Chen, Huangshuai Xu   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source