Results 41 to 50 of about 236,574 (263)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

High-stability flexible thin-film temperature sensor using MWCNTs-toughened Peano structure

Microsystems & Nanoengineering
Characterized by thinness, lightness and flexibility, flexible thin-film temperature sensors can be tightly fitted to different shapes of surfaces to measure their surface temperatures.
Zhaojun Liu, Bian Tian, Bogang Liu, Xiang Liu, Jiaming Lei, Jiangjiang Liu, Zhongkai Zhang, Chen Wu, Qijing Lin, Zhuangde Jiang   +9 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Gate-tunable flexible photodetector with wavelength-selective response based on asymmetric 2D heterostructures

Microsystems & Nanoengineering
Flexible photodetectors with wavelength-selective response are essential for next-generation wearable and bio-integrated optoelectronics. However, conventional devices typically rely on external filters or complex structures, limiting the flexibility ...
Ze Zhang, Peirui Ji, Wenbo Hu, Shenghan Qin, Shuhao Zhao, Hanjin Dong, Weihao Tao, Shuming Yang   +7 more
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

High-Efficiency Dynamic Scanning Strategy for Powder Bed Fusion by Controlling Temperature Field of the Heat-Affected Zone

Chinese Journal of Mechanical Engineering
Improvement of fabrication efficiency and part performance was the main challenge for the large-scale powder bed fusion (PBF) process. In this study, a dynamic monitoring and feedback system of powder bed temperature field using an infrared thermal ...
Xiaokang Huang, Xiaoyong Tian, Qi Zhong, Shunwen He, Cunbao Huo, Yi Cao, Zhiqiang Tong, Dichen Li   +7 more
doaj   +1 more source

Wheel Setting Error Modeling and Compensation for Arc Envelope Grinding of Large-Aperture Aspherical Optics

Chinese Journal of Mechanical Engineering, 2022
Precision grinding is a key process for realizing the use of large-aperture aspherical optical elements in laser nuclear fusion devices, large-aperture astronomical telescopes, and high-resolution space cameras.
Changsheng Li, Lin Sun, Zhaoxiang Chen, Jianfang Chen, Qijing Lin, Jianjun Ding, Zhuangde Jiang   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source