Results 131 to 140 of about 8,532,954 (271)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Omipalisib reduces hyperphosphorylated tau protein by modulating mTOR-autophagy pathway. [PDF]

PLoS One
Hwang H, Kim N, Jeon S, Lee Y, Son J, Jeon SH, Lee Y, Gee MS, Inn KS, Lee JK.   +9 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Mental illness stigma and its impact on help-seeking behavior among residents of the Eastern Region, Saudi Arabia: A cross-sectional study. [PDF]

PLoS One
Elmosaad YM, Alabdulqader Z, Alhaddad M, Aatif M, Al Jowf GI.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

David Reeve, "To remain myself; The history of Onghokham"

Wacana: Journal of the Humanities of Indonesia
Dick van der Meij
doaj   +1 more source

Case-control study of risk factors for abscess development following hepatitis B vaccination in children in Timor-Leste, 2024. [PDF]

PLoS One
da Silva Marques M, de Neri Machado F, Amaral Mali M, da Costa Sarmento N, Soares D, Gama Soares N, de Alexandria Barros C, Guterres Babo LNM, da C Silva AA, Adão Mendonça E, Jesus da Silva N, Barreto Dos Santos N, Neves MAAM.   +12 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Test-retest reliability and sensitivity of horizontal jump inter-limb asymmetry in youth soccer players across maturity stages. [PDF]

PLoS One
Hammami R, Negra Y, Ceylan HI, Selmi W, Morgans R, González-Fernández FT, Bragazzi NL.   +6 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source