Results 221 to 230 of about 9,455,846 (272)

Evaluation of a commercial AI-assisted cell counting software for dopaminergic neurons across species. [PDF]

PLoS One
Kunugitani K, Sawamura M, Taguchi T, Hirato T, Uemura N, Ayaki T, Nakanishi E, Yamakado H, Ishimoto T, Onoe H, Isa T, Matsumoto R, Takahashi R.   +12 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Rehabilitation outcomes following tail-fluke amputation in an Indo-Pacific bottlenose dolphin: A welfare-centered approach. [PDF]

PLoS One
Higa S, Takahashi S, Nakashima E, Kurosu Y, Ikeshima H, Yagi R, Adachi N, Ueda K, Umeyama H, Yamamoto H, Nakakita Y, Tochigi K, Kagawa T, Oka SI.   +13 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Study on the formation mechanism of color and flavor during the processing of Polygonatum cyrtonema Hua (PCH). [PDF]

PLoS One
Wang Z, Xie J, Sun M, Liu A, Zhou L, Yuan Y, Cai L, Xu R, Song R.   +8 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Civil society perspectives on tuberculosis care for people living with HIV in Brazil: A study informed by Social Representations Theory. [PDF]

PLOS Glob Public Health
Magnabosco GT, de Paulo Pedroso F, Palmieri IGS, de Souza LB, Sesnik HH, Soares Turquino SN, Lomes da Cruz KA, Nabas RM, do Carmo Antonio H, Resende MVF, Pavinati G.   +10 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Important Manuscript Collcctions Important Manuscript Collcctions

Ilha do Desterro, 2008
Ilha do Desterro
doaj  

The dolutegravir failure cohort: A multi-country longitudinal cohort with a randomised clinical trial of continued dolutegravir versus switch to darunavir in people with viraemia while on dolutegravir in Sub-Saharan Africa (The Ndovu Study) protocol. [PDF]

PLoS One
Ombajo LA, Nkuranga J, Penner J, Kamau EW, Ismael N, Munseri P, Ayakaka I, Labhardt N, Wamalwa D, Ramgi P, Chissumba RM, Wagude J, Bakari M, Omodi V, Otieno E, Abuogi L, Patel R, Opondo C, Grint D, King'wara L, Macharia A, Mulwa A, Amoth P, Ndovu study group.   +23 more
europepmc   +1 more source