Results 31 to 40 of about 4,025,753 (264)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Cologny, Fondation Martin Bodmer, Cod. Bodmer 703 : Collection of poems
The manuscript, written in modern Devanāgarī script, contains a series of extracts of poems on Rādhā and Kṛṣṇa and on nāyikās and nāyakas (heroes and heroines), demonstrating various states and stages of erotic love.
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Manuscript Collections, Archives, and Special Collections
Toutes ces collections sont generalement rassemblees sous une administration specialisee en livres rares. Cette approche qui s'etend aux manuscrits est depassee pour les fonds modernes de manuscrits, les techniques actuelles exigent une autonomie pour ces fonds.
openaire +2 more sources
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Zürich, Braginsky Collection, B57 : Siddur according to the Sephardic rite (Nussah Sefarad)
Apart from the daily prayers, this manuscript also contains kabbalistic commentaries and kavvanot (mystical intentions). In the kabbalistic school of Safed (Upper Galilee), the mystical aspect of prayer, as “the vehicle of the soul\u27s mystical ...
Luria, Yitsḥaḳ ben Shelomoh
core +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Collection of anonymous sermons (Quadragesima) from the early 14th century, containing 96 sermons. The foliation by Friedrich von Amberg (guardian in Fribourg, † 1432) indicates that the manuscript is incomplete.
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Zürich, Braginsky Collection, B26 : Pentateuch and Haftarot
This manuscript contains the full text of the Pentateuch and haftarot (weekly readings from the Prophets). The manuscript has six illuminated initial word panels found at the beginning of each of the books of the Pentateuch and at the heading of the ...
core +1 more source

