Results 41 to 50 of about 12,863,015 (313)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Zürich, Zentralbibliothek, Ms. Rh. hist. 33b : War technology (Illuminated Manuscript)
This codex contains a rare illuminated manuscript constituted entirely by illuminated pages, for each of which only a succinct caption is given, most often only a line of text, and which therefore provides exceptional historical image-sources for ...
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
St. Gallen, Stiftsbibliothek, Cod. Sang. 603 : Composite manuscript
Collection manuscript, 15th century, from the Dominican convent of St. Katharina in St. Gall. This German-language manuscript is made up of five fascicles and contains a treatise on the Passion of Christ (“Vierzig Myrrhenbüschel vom Leiden Christi‟): the
Sattler, Regina +3 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Basel, Universitätsbibliothek, B X 12 : Composite Manuscript
This composite manuscript is from the library of the Carthusian Monastery of Basel; it contains the first part of the Orationes et meditationes de vita Christi by the mystic Thomas à Kempis (1379-1471), one of the most important representatives of the ...
Heinrich Arnoldi +5 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Zürich, Braginsky Collection, B274 : Sefer Mitzvot Gadol (Large Book of Commandments)
This is the earliest known manuscript of Moses of Coucy\u27s classic legal code and also the earliest dated codex in the Braginsky Collection. The Sefer Mitzvot Gadol (abbreviated the SeMaG) became a major and accepted source of halakhic rulings.
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source