Results 61 to 70 of about 4,025,753 (264)
This manuscript from the library of Walter Supersaxo (ca. 1402-1482), Bishop of Sion, and of his son Georg (ca. 1450-1529) is a collection of literary French texts with moralizing tendencies; it contains the romance Pontus and Sidonia as well as 15th ...
Supersaxo, Georg +3 more
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FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Basel, Universitätsbibliothek, M VI 48 : Awrād-i šarīfa
Collection of prayers in the form of litanies (awrād), attributed to a Šayḫ Wafāʾ. The manuscript must have been completed before 1746, because in this year it was consigned to a religious foundation by Bašīr Āġā, a dignitary of the Ottoman court.
Tschudi, Rudolf
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Zürich, Braginsky Collection, B115 : Sefer Mitzvot Katan (Small Book of Commandments)
Isaac of Corbeil († 1280) is the author of this halakhic Small Book of Commandments also known as Sefer Mitzvot Katan (abbreviated SeMaK). This abridged version of the 613 positive and negative biblical commandments, and a few additional rabbinic ones ...
Moses, von Zürich
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Solothurn, Zentralbibliothek, Cod. S 451 : Solothurn Legendary
The Solothurn Legendary is the earliest example of a collection of legends in the German language. This manuscript was written during the second quarter of the 14th century in a Dominican cloister, possibly in Töss (near Winterthur) or in Oetenbach ...
Gotthard, Werner, Seuse, Heinrich
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Zürich, Braginsky Collection, B331 : Book on circumcision
This small-format manuscript from the 17th century contains hymnal prayers, poems and blessings for the circumcision ceremony. Two sections of the book contain illustrated pages. In addition to the title page, which is decorated with a Renaissance portal,
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source