Results 71 to 80 of about 12,863,015 (313)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Zürich, Braginsky Collection, B26 : Pentateuch and Haftarot
This manuscript contains the full text of the Pentateuch and haftarot (weekly readings from the Prophets). The manuscript has six illuminated initial word panels found at the beginning of each of the books of the Pentateuch and at the heading of the ...
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Collection of anonymous sermons (Quadragesima) from the early 14th century, containing 96 sermons. The foliation by Friedrich von Amberg (guardian in Fribourg, † 1432) indicates that the manuscript is incomplete.
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
БиблиосфераThe article examines current issues in the development of archaeography in Siberia, focusing on identifying Siberian manuscripts and collections within Moscow monasteries in the 19th and early 20th centuries, their circulation, and collection formation ...
N. К. Chernyshova
doaj +1 more source
Laboratoire Italien, 2018 The article aims at shedding light on a collection of prophetic texts contained in an early sixteenth-century Italian manuscript of medical prescriptions and prognostications from Florence and Ferrara (ms. 425, Wellcome Historical Medical Library, London)
Michela Del Savio
doaj +1 more source
Zürich, Braginsky Collection, B243 Vol. 1 : Hebrew Bible
At the end of the last volume (Vol. 4) of this Hebrew Bible with Masoretic comments (textual criticism) is the older colophon, which states that Isaac ben Ishai Sason completed it in 1491 in Ocaña, (Spain).
Botfield, Beriah
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Zürich, Braginsky Collection, B62 : De Pinto Psalter (Sefer Tehillim)
In 1728 Meir Cohen Belinfante copied this decorated psalter from the 1670 printed edition by the Amsterdam printer of Hebrew and Spanish books, David de Castro Tartas, who was active between 1662 and 1698. The manuscript has a decorated title page, which
core +1 more source