Results 91 to 100 of about 4,025,753 (264)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Genève, Bibliothèque de Genève, Ms. lat. 52 : Guido de Columnis, Historia destructionis Troiae

This manuscript contains the Latin translation of the Roman de Troie by Benoît de Sainte-Maure, prepared in 1287 by Guido de Columnis. The text is divided into 35 books, of which only 9 are introduced by miniatures, most of them whole-page miniatures (f.
Guido, de Columnis, Petau, Paul, Petau, Alexandre, Lullin, Ami, Benoît, de Sainte-More   +4 more
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Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Basel, Pharmaziemuseum der Universität Basel, Cod. H25 : Schoop Johann, "Recept-Büchlein, Allerhand kostbar Wasser zuo distilliern" (Recipe-Booklet, All kinds of precious water to distill)

This booklet contains a collection of recipes for producing medications, home remedies and foodstuffs. The presentation of the recipes ranges from lists of ingredients to detailed texts that describe the processing of the ingredients. The manuscript does
Schoop, Johann
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Basel, Universitätsbibliothek, D III 7 : Avicenna and Al-Gazali in Latin translation

This volume, written in littera parisiensis in the middle of the 13th century, contains Avicenna’s De anima in a translation by John of Seville, as well as parts from the Metaphysica, translated by Dominicus Gundissalinus.
Avicenna, Dominicus, Gundissalinus, Louber, Jakob, Heynlin, Johannes, Johannes, Hispalensis, Ġazzālī, Abū-Ḥāmid Muḥammad Ibn-Muḥammad al-   +5 more
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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bengali manuscript

Manuscript volume bound in red ...

core  

Sion/Sitten, Médiathèque Valais, S 105 : Terentius, Comoediae

This manuscript from the library of Walter Supersaxo (ca. 1402-1482), Bishop of Sion, and of his son Georges (ca. 1450-1529), contains Terence’s six comedies, each of which begins with an ornamental initial: Andria (f. 5r), Eunuchus (f.
Supersaxo, Georg, Terentius Afer, Publius, Supersaxo, Walter   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source