Results 81 to 90 of about 12,863,015 (313)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Developing a Teaching Collection of Manuscript Fragments at a Regional Comprehensive Institution

New Chaucer Studies
This essay shares the author's experiences of developing a teaching collection of medieval manuscript materials at a state school whose Special Collections library is relatively small, recently established, and modestly funded.
Kathryn R Vulic
doaj   +1 more source

Zürich, Braginsky Collection, B124 : Jacob ben Asher, Tur Orah Hayyim ("Row: Way of Life")

This manuscript by Jacob ben Asher (son of the rabbi and codifier Asher ben Jehiel) contains one of the oldest copies of the Jewish code Arba’ah Turim. The entire work treats all rules of Jewish law concerning prayers and the synagog.
Yaʿaḳov ben Asher
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Solothurn, Zentralbibliothek, Cod. S 392 : Composite manuscript with art technology recipes

This substantial composite manuscript contains approximately 2.000 recipes and instructions, principally from art technology, but also other medical, culinary and alchemistic ones.

core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Basel, Universitätsbibliothek, B X 8 : Composite manuscript with material for sermons

This manuscript for regular use consists of four parts; it contains material for preparing sermons, including a register of sermon topics, an extensive corpus of legends and more than 100 exempla.
Jakob, von Vitry, Louber, Jakob, Jacobus, de Voragine, Loy, Johannes, Carpentarii, Georgius, Moser, Urban   +5 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Basel, Universitätsbibliothek, A VIII 36 : Collection of hagiographic texts

This composite manuscript in German is from the Convent of Dominican nuns of St. Maria Magdalena “an den Steinen” in Basel, which was reformed in 1423; most of the manuscript was probably written there as well.
Biberli, Marquard, Theodoricus, de Apolda   +1 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source