Results 91 to 100 of about 114,970 (245)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Advancing the multi-disciplinarity of parasitology within the British Society for Parasitology: studies of host-parasite evolution in an ever-changing world. [PDF]
, 2018 The study of parasites typically crosses into other research disciplines and spans across diverse scales, from molecular- to populational-levels, notwithstanding promoting an understanding of parasites set within evolutionary time.
Webster, B. L. +3 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Iranian traditional medicine and Medicinal plants [PDF]
, 2019 Traditional medicine is a general word referring to both tradiotional medicine systems and to Native medicine. Iranian traditional medicine is a great history of medicine and pharmacy.to inform the importance of Iranian traditional medicine we may state ...
Mohammad Taqi khammar (6830884) +3 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
"It gave me relief...it gave me confidence" - the online health information seeking experiences of adults with chronic health conditions. [PDF]
Background- The recent modernisation of the United Kingdom (UK) National Health Service (NHS) has included a number of sizeable reforms that have emphasised partnership relationships between patients and professionals, and the importance of individuals ...
Mayoh, Joanne
core
Publishing cooperative and work-integrated education literature: The Asia-Pacific Journal of Cooperative Education [PDF]
, 2012 The Asia-Pacific Journal of Cooperative Education (APJCE) was founded in 1999, with the first volume published in 2000. The journal strongly adhered to the philosophy of having freely and readily accessible information, and opted to be a free, fully ...
Zegwaard, Karsten E.
core