Results 81 to 90 of about 114,970 (245)

The Poor and the Patient: Protestant Geneva in the Early Modern Period 1 [PDF]

open access: yes, 2014
ecent research has demonstrated the usefulness of considering both the history of lay and professional practices from the patient’s point of view. Issues explored include the interactions between the ill and contemporary healers 2, between medical ...
Philip Rieder
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The cooperation agreement beetwen the university of l'Aquila, Italy and the Marat Ospanov west-Kazakistan stare medical university, the republic of Kazakistan: a successful story fron academy to bench [PDF]

open access: yes, 2015
During the spring-summer of 2014, the first exchange program foreseen the research mobility from Kazakhstan to Italy. An academic staff member and a PhD student of the Marat Ospanov WestKazakhstan State Medical University spent three months of research ...
Rakhmanov, S.   +11 more
core  

OBML - Ontologies in Biomedicine and Life Sciences. [PDF]

open access: yes, 2011
The OBML 2010 workshop, held at the University of Mannheim on September 9-10, 2010, is the 2nd in a series of meetings organized by the Working Group "Ontologies in Biomedicine and Life Sciences" of the German Society of Computer Science (GI) and the ...
Schulz, Stefan   +14 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

LOOKING AHEAD TO 2026

open access: yesПраці Наукового товариства імені Шевченка. Медичні науки
Dear reader, We have entered the final year of the first quarter of the 21st century, which will be eternally marked by the catastrophic challenges linked to numerous global military conflicts and the COVID-19 pandemic.
Oksana Zayachkivska   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Clinical molecular genetics in the UK c.1975-c.2000 [PDF]

open access: yes, 2014
seminar transcriptChaired by Professor Martin Bobrow and introduced by Professor Bob Williamson, this Witness Seminar included geneticists from a broad range of research and clinical specialities.
Jones, EM, Tansey, EM
core  

The evolution of medicine trought Renaissance [PDF]

open access: yes
This review of historical medical literature aims to portray the relationship between the philosophical identity of ancient Greece and Christianity and medical progress.
Ballini A.   +6 more
core   +1 more source

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