Results 61 to 70 of about 56,242,976 (256)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Characterization of Research Mentorship During Medical School for Future Radiation Oncology Trainees

Advances in Radiation Oncology
Purpose: Medical student access to radiation oncology (RO) research opportunities is important for stimulating interest in the specialty. The purpose of this study was to assess the publication record during medical school of students who ultimately ...
Marisa Palmeri, MBS, Kristy Bono, MS, Austin Huang, BSA, Jillian R. Gunther, MD, PhD, Malcolm D. Mattes, MD   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Role Use, Intellectual Structure Evolu-tion, and the Co-occurrence Topic Net-work of Vocabulary: The Domain of Role Classifications and Ontologies of Participants [PDF]

پژوهشنامه علم سنجی
Purpose: Contributor Role Taxonomy (CRediT) offers a standardized set of 14 roles—including conceptualization, methodology, software, validation, formal analysis, investigation, resources, data curation, writing (original draft), writing (review and ...
Elaheh Hosseini, Mohammad Hosseini, Maral Alipour-Tehrani   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Malay medical manuscripts: heritage from the garden of healing

, 2017
The Malay Archipelago is like a garden rich in plants, animals, and minerals of medicinal benefits. The healing tradition of the Malays utilises these resources, and Malay medical practitioners documented their uses alongside descriptions of diseases in ...

core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

THE HABANERO PEPPER (Capsicum chinense JACQ.) AS A STUDY PLANT MODEL IN MEXICO

Tropical and Subtropical Agroecosystems, 2020
Background. Habanero pepper (Capsicum chinense Jacq.) is a vegetable of economic interest, its fruits have unique characteristics of flavor and pungency. Its pungency is due to the capsaicinoids, which were the starting research interest on this crop. In
Rocío Elizabeth Meneses Lazo, René Garruña   +1 more
doaj  

On Research and Publication: the Specialty Society and its Scholarly Journal

Philippine Journal of Otolaryngology Head and Neck Surgery, 2013
“Research, no matter how ‘good’, is incomplete, until it has been published.”1   The Philippine Society of Otolaryngology Head and Neck Surgery has been promoting research among Residents and Fellows through various fora (including research ...
José Florencio F. Lapeña
doaj   +1 more source