Results 51 to 60 of about 137,662 (243)

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

THE HABANERO PEPPER (Capsicum chinense JACQ.) AS A STUDY PLANT MODEL IN MEXICO

open access: yesTropical and Subtropical Agroecosystems, 2020
Background. Habanero pepper (Capsicum chinense Jacq.) is a vegetable of economic interest, its fruits have unique characteristics of flavor and pungency. Its pungency is due to the capsaicinoids, which were the starting research interest on this crop. In
Rocío Elizabeth Meneses Lazo   +1 more
doaj  

Clinical Genetics in Britain: Origins and development [PDF]

open access: yes, 2010
Annotated and edited transcript of a Witness Seminar held on 23 September 2008. Introduction by Professor Sir John Bell, Uiversity of Oxford.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2010.©The Trustee of the ...
Harper, PS, Reynolds, LA, Tansey, EM
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A New Era of the Fresh Start [PDF]

open access: yesReviews in Clinical Medicine, 2014
The Journal of Reviews in Clinical Medicine (RCM) is the leading journal of its type at Mashhad University of Medical Sciences covering all aspects of the natural and clinical sciences, which may be a matter of concern for the related specialists.
Hamid Reza Kianifar
doaj  

A history of the Scandinavian Journal of Work, Environment & Health

open access: yesScandinavian Journal of Work, Environment & Health, 2016
The Nordic countries have a long history of providing occupational health services, with legislation being passed as early as 1873 in Denmark and 1889 in Sweden and Finland (1).
Derek R Smith
doaj   +1 more source

The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 statement [PDF]

open access: yes, 2016
We developed a reporting guideline to provide authors with guidance about what should be reported when writing a paper for publication in a scientific journal using a particular type of research design: the single-case experimental design.
Albin, Richard   +25 more
core   +1 more source

Home - About - Disclaimer - Privacy